From Concern to Control: Feedback from a quality improvement project to decrease Central-Line–Associated Bloodstream Infections in a Tertiary Neonatal Intensive Care Unit"
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Abstract
Introduction: Infants admitted in Neonatal Intensive Care units (NICU) are frequently exposed to a high risk of contracting a central line-associated bloodstream infection (CLABSI). The study aims to reduce the CLABSI rate in the NICU to reach the Saudi Ministry of Health (MOH) benchmark.
Methods: It is a quality improvement project based on the Plan Do Check Act. This study was conducted in the Neonatal intensive care unit (NICU) at the Prince Sultan Military Medical City. The study was done from February 2023 to July 2023 in NICU. Sixteen evidence-based recommendations were assessed over the project. An assigned team enhanced the regular assessment of central line-related items and supplies.
Results: 38 staff members were selected as 'a vascular access team' for this project. Full compliance with updated recommendations increased from 25% to 56.3%, and overall care bundle compliance improved from 66.07% to 79.12%. The availability of supplies related to central lines improved throughout the CLABSI project. Consequently, the CLABSI rate decreased by 82.3%, from 10.42 (6 CLABSI, 576 central line days; February 2023) to 1.84 (1 CLABSI, 544 central line days; July 2023) CLABSI per 1,000 central line days after six months of quality improvement project implementation.
Conclusions: Reducing the CLABSI rate is achievable by QIP based on updated recommendations to improve the quality of care and outcomes for newborns. However, multiple challenges should be addressed to maintain a low CLABSI rate.
Keywords:
Central line, associated bloodstream infections , Quality improvement project , Neonatal intensive care unit##plugins.themes.academic_pro.article.details##

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References
- Nielsen C.L., Zachariassen G., Holm K.G. Central line-associated bloodstream infection in infants admitted to a level lllneonatal intensive care unit. Danish Medical Journal 2022; 69 (5): A05210463.
- Khieosanuk K, Fupinwong S, Tosilakul A, Sricharoen N, Sudjaritruk T. Incidence rate and risk factors of central line-associated bloodstream infections among neonates and children admitted to a tertiary care university hospital. American Journal of Infection Control 2022;50 (1): 105-107.
- Shabbir H.A, Mohyuddin A.A, Saba A, et al. CLABSI reduction using evidence-based interventions and nurse empowerment: a quality improvement initiative from a tertiary care NICU in Pakistan. Archives of Disease in Childhood 2021; 106 (4): 394-400.
- Muller Martha, Bryant Kristina A, Espinosa Claudia, Jones Jill A, Quach Caroline, Rindels Jessica R. SHEA Neonatal Intensive Care Unit (NICU) White Paper Series: Practical approaches for the prevention of central-line–associated bloodstream infections. Infection Control & Hospital Epidemiology 2023; 44: 550-564.
- O’grady N.P., Alexander, Burns L.A, et al. Summary of Recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis. 2011; 52(9): 1087–1099.
- Hsu H.E, Mathew R, Wang R, et al. Health care–associated infections among critically ill children in the US, 2013-2018. JAMA pediatrics 2020; 174 (12): 1176-1183.
- O’grady Naomi P, Alexander Mary, Burns Lillian A, et al. Guidelines for the prevention of intravascular catheter-related infections, 2011. Last update by Centers for Disease prevention and Control (CDC): October 2017. Acessible on URL: www.cdc.gov/infection-control/media/pdfs/Guideline-BSI-H.pdf
- Chien, Li-Yin, Macnab Y, et al. Canadian Neonatal Network.
- LA TUNISIE MEDICALE - 2025 ; Vol 103 (n°09)
- Variations in central venous catheter-related infection risks among
- Canadian neonatal intensive care units. The Pediatric infectious
- disease journal 2002;21(6): 505-511.
- Debby Ben-David, Vaturi Azza, Wulffhart Liat, Temkin Elizabeth,
- Solter Ester, Carmeli Yehuda. Impact of intensified prevention
- measures on rates of hospital-acquired bloodstream infection
- in medical-surgical intensive care units, Israel, 2011 to 2019. Euro
- Surveill. 2023; 28(25): 2200688.
- Buetti N, Marschall J, Drees M, et al. Strategies to prevent central
- line-associated bloodstream infections in acute-care hospitals:
- Update. Infection Control & Hospital Epidemiology 2022;
- (5): 553-569.
- Centers for Disease Control and Prevention (CDC). National
- Center for Emerging and Zoonotic Infectious Diseases. Division of
- Healthcare Quality Promotion. Recommendations for Prevention
- and Control of Infections in Neonatal Intensive Care Unit Patients:
- Central Line-associated Blood Stream Infections. February 2022.
- Accessible version: https://www.cdc.gov/infectioncontrol/
- guidelines/nicu-clabsi/index.html
- Center for Disease Prevention and Control of Atlanta (CDC).
- National Healthcare Safety Network (NHSN). Bloodstream Infection
- Event (Central Line-Associated Bloodstream Infection and Noncentral
- Line Associated Bloodstream Infection). January 2024.
- Michael M.Hermon. Central lines and Their Complications in
- Neonates: A case Report and Literature Review. Children (Basel)
- ; 11(1):26.
- Mostafa FA, Alnafee K, Al Shanqiti K, Siddiq N, Alshuhri S, Badawi D.
- Reducing central-line–associated bloodstream infections (CLABSI):
- an improvement project in a specialized tertiary hospital. Global
- Journal on Quality and Safety in Healthcare. 2022 Nov 1;5(4):84-92.
- Hye Jung Cho, Hye-Kyung Cho. Central line- associated bloodstream
- infections in neonates. Korean J Pediatr 2019 ; 62 (3) :79-84.
- Fisher D, Cochran KM, Provost LP, et al. Reducing central line–
- associated bloodstream infections in North Carolina NICUs.
- Pediatrics. 2013;132(6):e1664-71.
- Schulman J, Stricof R, Stevens TP, et al. Statewide NICU central-lineassociated
- bloodstream infection rates decline after bundles and
- checklists. Pediatrics. 2011;127(3):436-44.
- Ista E, van der Hoven B, Kornelisse RF, et al. Effectiveness of
- insertion and maintenance bundles to prevent central-lineassociated
- bloodstream infections in critically ill patients of all
- ages: a systematic review and meta-analysis. The Lancet Infectious
- Diseases. 2016 ;16(6):724-34.
- Payne V, Hall M, Prieto J, Johnson M. Care bundles to reduce
- central line-associated bloodstream infections in the neonatal
- unit: a systematic review and meta-analysis. Archives of Disease in
- Childhood-Fetal and Neonatal Edition. 2018;103(5):F422-9.
- Al Bizri A, Wakim RH, Obeid A, et al. A Quality improvement
- initiative to reduce central line-associated bloodstream infections
- in a neonatal intensive care unit in a low-and-middle-income
- country. BMJ Open Quality. 2023;12(2):e002129.
- Carr PJ, Higgins NS, Cooke ML, Mihala G, Rickard CM. Vascular
- access specialist teams for device insertion and prevention of
- failure. Cochrane Database of Systematic Reviews. 2018(3).
- Bierlaire S, Danhaive O, Carkeek K, Piersigilli F. How to minimize
- central line–associated bloodstream infections in a neonatal
- intensive care unit: a quality improvement intervention based on
- a retrospective analysis and the adoption of an evidence-based
- bundle. European journal of pediatrics. 2021;180:449-60.
- Scheier T, Saleschus D, Dunic M, et al. Implementation of daily
- chlorhexidine bathing in intensive care units for reduction of
- central line-associated bloodstream infections. Journal of Hospital
- Infection. 2021;110:26-32.
- Afonso E, Blot K, Blot S. Prevention of hospital-acquired bloodstream
- infections through chlorhexidine gluconate-impregnated washcloth
- bathing in intensive care units: a systematic review and metaanalysis
- of randomised crossover trials. Eurosurveillance. 2016 Nov
- ;21(46):30400.
- Moureau N.L., Flynn J. Disinfection of Needleless Connector Hubs:
- Clinical Evidence Systematic Review. Nurs Res Pract. 2015; 2015:
- Association for Professionals in Infection Control and
- Epidemiology. Guide to Preventing Central Line-Associated
- Bloodstream Infections. APIC implementation guide. First edition,
- December 2015. Accessible on: https://apic.org/Resource_/
- TinyMceFileManager/2015/APIC_CLABSI_WEB.pdf
- Marschall J, Mermel LA, Fakih M, et al. Strategies to prevent
- central line-associated bloodstream infections in acute care
- hospitals: 2014 update. Infection Control & Hospital Epidemiology.
- ;35(S2):S89-107.
- Chopra V, Krein S, Olmstead R, Safdar N, Saint S. Making Health
- Care Safer II: An Updated Critical Analysis of the Evidence for
- Patient Safety Practices. Comparative Effectiveness Review No.
- chapter 10. Santa Monica, Calif, USA: RAND Corporation, US
- Department of Health and Human Services, Agency for Healthcare
- Research and Quality; 2013. Prevention of central line-associated
- bloodstream infections: brief update review; pp. 88–109.
- Lee J. Disinfection cap makes critical difference in central line
- bundle for reducing CLABSIs. American Journal of Infection Control.
- ;39(5):E64.
- Sweet MA, Cumpston A, Briggs F, Craig M, Hamadani M. Impact
- of alcohol-impregnated port protectors and needleless neutral
- pressure connectors on central line–associated bloodstream
- infections and contamination of blood cultures in an inpatient
- oncology unit. American journal of infection control.
- ;40(10):931-4.
- Flynn JM, Larsen EN, Keogh S, Ullman AJ, Rickard CM. Methods
- for microbial needleless connector decontamination: a systematic
- review and meta-analysis. American Journal of Infection Control.
- ;47(8):956-62.
- Stango C, Runyan D, Stern J, Macri I, Vacca M. A successful approach
- to reducing bloodstream infections based on a disinfection device
- for intravenous needleless connector hubs. Journal of Infusion Nursing. 2014;37(6):462-5.