Polyphenols as Epigenetic Modulators of Health: A Holistic Approach to the Therapy and Prevention of Chronic Diseases

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Published Dec 27, 2025
https://doi.org/10.62438/tunismed.v103i10.5892
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Vol. 103 No. 10 (2025): Tunis Med Oct 2025

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Sara Gheribi
Polish University – Foundation
https://orcid.org/0000-0001-7626-7578

Abstract

Background: The rising prevalence of chronic diseases, including cancer, metabolic disorders, neurodegenerative, and cardiovascular conditions, presents a growing challenge to modern medicine and public health.


Aim: This article investigates the potential of polyphenols as modulators of epigenetic mechanisms in the context of chronic disease.


Methods: A comprehensive review of scientific literature was conducted, with emphasis on key epigenetic processes such as DNA methylation, histone modifications, and microRNA regulation.


Results: Polyphenols like resveratrol, curcumin, quercetin, and catechins exert protective actions by modulating gene expression, counteracting harmful epigenetic changes, and supporting cellular health.


Conclusion: Advancing our understanding of how polyphenols influence epigenetic pathways may lead to innovative therapeutic strategies combining conventional and personalized approaches.

Keywords:

Polyphenols, Epigenetics, Chronic Diseases, DNA Methylation, Epigenetic Modulators, Nutrigenomics, Antioxidants, Health, Therapeutic Strategies, Prevention

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Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biography

Sara Gheribi, Polish University – Foundation

Co-founder; https://orcid.org/0000-0001-7626-7578

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