Synergistic Effect of Noise and Toluene Upon Hematological Alterations, Pulmonary Oxidative Stress and Inflammation.

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Published Dec 27, 2025
https://doi.org/10.62438/tunismed.v103i10.5718
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Vol. 103 No. 10 (2025): Tunis Med Oct 2025

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Takwa Ben Attia
Laboratory of Research "LR 23/ES/10": Population Pathology, Environmental Aggressors, Alternative Therapy, Unit of Experimental Medicine, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Noura Gannouni
Laboratory of Research "LR 23/ES/10": Population Pathology, Environmental Aggressors, Alternative Therapy, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Said Galai
Research Laboratory of Neurological Diseases of the Child (LR18SP04), Department of Clinical Biology , National Institute Mongi Ben Hmida of Neurology at Tunis, Tunisia
Abada Mhamdi
Laboratory of Research "LR 23/ES/10": Population Pathology, Environmental Aggressors, Alternative Therapy, Unit of Experimental Medicine, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia

Abstract

Aim: Study the synergistic effects of noise-toluene co-exposure on hematological parameters, oxidative stress and pulmonary architecture in rats.


Methods: 24 male Wistar rats were divided into four groups: control, noise exposure, toluene exposure and co-exposure noise-toluene.


Biological analyses were performed to determine hematological parameters and evaluate markers of oxidative stress. Histopathological sections were observed to assess pulmonary tissue damage and the degree of inflammatory response.


Results: Hematological analysis revealed a significant decrease in red blood cells (RBCs), accompanied by an increase in white blood cells (WBCs) and platelets.


Histological examination of lung tissues revealed inflammation with alveolar wall damage and peribronchial immune cell infiltration in the co-exposed group, which correlated with increased vascular permeability and pulmonary edema.


Exposure to toluene and noise resulted in significant disruption of the pulmonary tissue structure accompanied by oxidative stress,


Conclusion: The results suggest that combined exposure to toluene and noise causes structural and functional changes in lung tissues and alterations in hematological parameters

Keywords:

Noise , Toluene, Lung , Coexposition , Oxidative stress , Pulmonary inflammation

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