Exploring risk factors and survival rates in invasive cervical carcinoma: New perspectives

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Published Aug 1, 2025
https://doi.org/10.62438/tunismed.v103i8.5691
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Vol. 103 No. 8 (2025): Tunis Med Aug 2025

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Amina Belhadj
Biology department, Biology of Development and Differentiation Laboratory, Oran 1 University Ahmed Ben Bella, Oran, Algeria
Youssera Khadidja Boumeddane
Service de biologie, Université d'Oran 1 Ahmed Ben Bella, Oran, Algérie
Djihane Meddah
Biology department, Oran 1 University, Ahmed Ben Bella, Oran, Algeria
Tewfik Sahraoui
Biology department, Biology of Development and Differentiation Laboratory, Oran 1 University Ahmed Ben Bella, Oran, Algeria

Abstract

Introduction: Cervical cancer is a public health issue in Algeria, it ranks at second position among female cancers.


Aim: This study sought to identify risk factors for cervical cancer and to determine their impact on patient survival


Methods: This is a retrospective study on 200 patients diagnosed during a 3-years period between January 1, 2016 and December 31, 2018. This study investigated cervical cancer risk factors and survival outcomes associations. The analysis was made by Chi Square test.  The progression-free survival rate was estimated using the Kaplan–Meier method.


Results: Our study revealed that squamous cell carcinoma was the most frequent diagnosis (69.9%), it also points to early sexual activity as a significant associated risk factor (P=0.05). This finding contrasts with the relatively small proportion of cases (12.12%) linked to hereditary causes. Patients with adenocarcinoma had a lower progression-free survival (PFS) (Log-Rank test P = 0.04). Poorer PFS was associated with earlier FIGO stages (Breslow: P =0.04; Tarone-Ware: P =0.04). Age at first sexual encounter and parity, however, did not significantly predict PFS. PFS was substantially better in T1-T2 pathological stages (P = 0.000).


Conclusion: The prognosis depends on knowing these risk factors. Understanding these characteristics is crucial for improved therapy and results. We provide an up-to-date insight of current cervical cancer risk factors in oran city. These results highlight how crucial it is to comprehend risk variables and how they affect the prognosis of cervical cancer.

Keywords:

Cervix, cancer, risk factors, progression-free survival, Algeria

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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