Post stroke seizures and Vascular epilepsy

##plugins.themes.academic_pro.article.main##

Samira Er-riouiche
Asma El tahiri
Siham Bouchal
Naima Chtaou
Aouatef El Mildaoui
Faouzi Belahsen
Zouhayr Souirti

Abstract

Introduction: Stroke (Cerebrovascular Accident, CVA), whether ischemic or hemorrhagic, is one of the main causes of epilepsy in the elderly. This condition leads to an increased risk of post-stroke seizures, affecting both patients' functional recovery and their quality of life. (1,2)


Aim: to clarify and simplify the management of vascular epilepsy, based on recent expert recommendations. This study seeks to address the specific challenges related to the incidence of post-stroke seizures, considering the clinical characteristics and therapeutic needs of patients who have experienced a stroke.


Methods: An analysis of available studies was conducted, considering different stroke subtypes, timing of seizure onset, and risk factors such as age, comorbidities, and stroke severity. Current recommendations for managing vascular epilepsy were also included.


Results: The results show variability in the incidence of seizures depending on stroke subtype and timing post-stroke. They also highlight a lack of consensus regarding certain risk factors and suitable management strategies.


Conclusion: This study emphasizes the need for clear guidelines for managing post-stroke epilepsy, especially for high-risk elderly patients. Current recommendations provide useful insights, but further research is needed to better define risk factors and optimize management strategies.

Keywords:

Stroke, early epileptic seizure, vascular epilepsy, anti-epileptic medications

##plugins.themes.academic_pro.article.details##

References

  1. Camilo O, Goldstein LB. Seizures and epilepsy after ischemic stroke. Stroke 2004;35(7):1769–75.
  2. Stefan H. Epilepsy in the elderly: facts and challenges. Acta Neurol Scand 2011;124(4):223–37.
  3. Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010;51(4):671–5.
  4. Fisher RS. The new classification of seizures by the International League against Epilepsy 2017. Curr Neurol Neurosci Rep 2017;17(6):48.
  5. Wang JZ, Vyas MV, Saposnik G, Burneo JG. Incidence and management of seizures after ischemic stroke: Systematic review and meta-analysis. Neurology 2017;89(12):1220–8.
  6. European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis Basel Switz 2008;25(5):457–507.
  7. Haapaniemi E, Strbian D, Rossi C, Putaala J, Sipi T, Mustanoja S, et al. The CAVE score for predicting late seizures after intracerebral hemorrhage. Stroke 2014;45(7):1971–6.
  8. Roivainen R, Haapaniemi E, Putaala J, Kaste M, Tatlisumak T. Young adult ischaemic stroke related acute symptomatic and late seizures: risk factors. Eur J Neurol 2013;20(9):1247 55.
  9. Lamy C, Domigo V, Semah F, Arquizan C, Trystram D, Coste J, et al. Early and late seizures after cryptogenic ischemic stroke in young adults. Neurology 2003;60(3):400–4.
  10. Galovic M, Ferreira-Atuesta C, Abraira L, Döhler N, Sinka L, Brigo F, Bentes C, Zelano J, Koepp MJ. Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management. Drugs Aging. 2021 Apr;38(4):285-299. doi: 10.1007/s40266-021-00837-7. Epub 2021 Feb 23. PMID: 33619704; PMCID: PMC8007525.
  11. Thevathasan A, Naylor J, Churilov L, Mitchell PJ, Dowling RJ, Yan B, et al. Association between hemorrhagic transformation after endovascular therapy and poststroke seizures. Epilepsia.
  12. Leung T, Leung H, Soo YOY, Mok VCT, Wong KS. The prognosis of acute symptomatic seizures after ischaemic stroke. J Neurol Neurosurg Psychiatry 2017;88(1):86–94.
  13. Kim HJ, Park KD, Choi K-G, Lee HW. Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure. BMC Neurol 2016;16(1):212.
  14. Serafini A, Gigli GL, Gregoraci G, Janes F, Cancelli I, Novello S, et al. Are early seizures predictive of epilepsy after a stroke? Results of a population-based study. Neuroepidemiology 2015;45(1):50–8.
  15. Neshige S, Kuriyama M, Yoshimoto T, Takeshima S, Himeno T, Takamatsu K, et al. Seizures after intracerebral hemorrhage; risk factor, recurrence, efficacy of antiepileptic drug. J Neurol Sci 2015;359(1–2):318–22.
  16. Denier C, Masnou P, Mapoure Y, Souillard-Scemama R, Guedj T, The´audin M, et al. Watershed infarctions are more prone than other cortical infarcts to cause early-onset seizures. Arch Neurol 2010;67(10):1219–23.
  17. Beghi E, D’Alessandro R, Beretta S, Consoli D, Crespi V, Delaj L, et al. Incidence and predictors of acute symptomatic seizures after stroke. Neurology 2011;77(20):1785–93.
  18. Rumbach L, Sablot D, Berger E, Tatu L, Vuillier F, Moulin T. Status epilepticus in stroke: report on a hospital-based stroke cohort. Neurology 2000;54(2):350–4.
  19. Giroud M, Gras P, Fayolle H, Andre´N, Soichot P, Dumas R. Early seizures after acute stroke: a study of 1640 cases. Epilepsia 1994;35(5):959–64.
  20. Carrera E, Michel P, Despland P-A, Maeder-Ingvar M, Ruffieux C, Debatisse D, et al. Continuous assessment of electrical epileptic activity in acute stroke. Neurology 2006;67(1):99–104.
  21. Jungehulsing GJ, Heuschmann PU, Holtkamp M, Schwab S, Kolominsky-Rabas PL. Incidence and predictors of post stroke epilepsy. Acta Neurol Scand 2013;127(6):427–30.
  22. Slapø GD, Lossius MI, Gjerstad L. Poststroke epilepsy: occurrence, predictors and treatment. Expert Rev Neurother 2006;6(12):1801–9.
  23. Stefan H, Michelson G. Late onset epilepsy and stroke: Diagnosis, pathogenesis and prevention. Seizure. 2024 Jun 12:S1059-1311(24)00168-7. doi: 10.1016/j.seizure.2024.06.011. Epub ahead of print. PMID: 38918106.
  24. Sarfo FS, Akassi J, Obese V, Adamu S, Agbenorku M, Ovbiagele B. Prevalence and predictors of post-stroke epilepsy among Ghanaian stroke survivors. J Neurol Sci. 2020 Nov 15;418:117138. doi: 10.1016/j.jns.2020.117138. Epub 2020 Sep 12. PMID: 32947087.
  25. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 2014;55(4):475–82.
  26. Galovic M, Dohler N, Erdelyi-Canavese B, et al. Prediction of late seizures after ischaemic stroke with a novel prognostic model (the SeLECT score): a multivariable prediction model development and validation study. Lancet Neurol. 2018;17(2): 143-152.doi:10.1016/S1474-4422(17)30404-0
  27. Tanaka T,Fukuma K,Abe S, et al. Association of cortical superficial siderosis with post-stroke epilepsy.AnnNeurol.2023;93(2):357-370.
  28. Strzelczyk A,Haag A,Raupach H,Herrendorf G,Hamer HM,Rosenow F. Prospective evaluation of a post-stroke epilepsy risk scale. J Neurol. 2010;257(8): 1322-1326.
  29. Holtkamp M,Beghi E,Benninger F,et al. European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy. Eur Stroke J. 2017;2: 103-115.doi:10.1177/2396987317705536
  30. Fang J,Tuo M,Ouyang K,XuY. Statin on post-stroke epilepsy : a systematic review and meta-analysis. JClinNeurosci.2021;83:83-87.doi:10.1016/j.jocn.2020.11.023
  31. ZhuY,GouH,MaL,et al. Effects of double-dose statin therapy for the prevention of post-stroke epilepsy: a prospective clinical study. Seizure. 2021;88:138-142. doi:10.1016/j.seizure.2021.04.010
  32. Tanaka T, Fukuma K, Abe S, et al. Antiseizure medications for post-stroke epilepsy: a real-world prospective cohort study. Brain Behav. 2021;11(9):e2330. doi:10.1002/ brb3.2330
  33. Lattanzi S, Trinka E, Del Giovane C, Nardone R, Silvestrini M, Brigo F. Antiepileptic drug monotherapy for epilepsy in the elderly: a systematic review and network meta analysis. Epilepsia. 2019;60(11):2245-2254. doi:10.1111/epi.16366
  34. Ryvlin P, Montavont A, Nighoghossian N. Optimizing therapy of seizures in stroke patients. Neurology 2006;67(12 Suppl 4):S3–9
  35. Rainesalo S, Ma¨kinen J, Raitanen J, Peltola J. Clinical management of elderly patients with epilepsy; the use of lacosamide in a single center setting. Epilepsy Behav EB 2017;75:86–9.
  36. Sarkis RA, Nicolas J, Lee JW. Tolerability of lacosamide or zonisamide in elderly patients with seizures. Seizure 2017;49:1–4.
  37. Pascarella A, Manzo L, Gasparini S, Marsico O, Abelardo D, Torino C, Cianci V, Iudice A, Bisulli F, Bonanni P, Caggia E, D'Aniello A, Di Bonaventura C, DiFrancesco JC, Domina E, Dono F, Gambardella A, Fortunato F, Marini C, Marrelli A, Matricardi S, Morano A, Paladin F, Renna R, Piccioli M, Striano P, Ascoli M, La Neve A, Le Piane E, Orsini A, Di Gennaro G, Aguglia U, Ferlazzo E; PEROC Study Group. Perampanel in post-stroke epilepsy: Clinical practice data from the PERampanel as Only Concomitant antiseizure medication (PEROC) study. J Neurol Sci. 2024 Jul 15;462:123106. doi: 10.1016/j.jns.2024.123106. Epub 2024 Jun 21. PMID: 38925069.