Effect of paracetamol on blood pressure: A systematic review protocol

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Published May 1, 2025
https://doi.org/10.62438/tunismed.v103i5.5525
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Vol. 103 No. 5 (2025): Tunis Med May 2025

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Saoussen Miladi
Rheumatology department, Mongi Slim Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Leila Rouached
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Selma Bouden
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Hiba Boussaa
Rheumatology department, Mongi Slim Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Yasmine Makhlouf
Rheumatology department, Mongi Slim Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Aicha Ben Tekaya
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Ines Mahmoud
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Rawdha Tekaya
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Olfa Saidane
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Kawther Ben Abdelghani
Rheumatology department, Mongi Slim Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Alia Fazaa
Rheumatology department, Mongi Slim Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Leila Abdelmoula
Rheumatology department, Charles Nicolle Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
Ahmed Laatar
Rheumatology department, Mongi Slim Hospital, Tunis. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia

Abstract

Introduction: Paracetamol is widely used as a first-line treatment for chronic pain because it is thought to be safe. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol is thought to have no cardiovascular effects and specially no effect on blood pressure (BP). However, some studies suggest that paracetamol may increase BP. Thus, our aim was to address a systematic review in order to investigate the effects of regular paracetamol intake on BP.


Methods: To address this systematic review, a search on PubMed, Cochrane and Scopus is planned. A search on grey literature, registries, thesis and congress abstracts will be performed. We will include randomized clinical trials, interventional studies and observational studies. Studies on child bearing women and those with eclampsia or preeclampsia will be excluded. Besides, only studies using recommended dosage of paracetamol will be included. The primary outcomes of interest will be the change of BP before and after the intake of paracetamol. 


Discussion:   Change of BP will be assessed on patients taking paracetamol. Any previous cardiovascular disease or hypertension will be raised in order to identify if there are risk factors of hypertension under paracetamol. 

Keywords:

acetaminophen, hypertension, systolic blood pressure, diastolic blood pressure, adverse effect

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