Diagnostic and therapeutic approach to endobronchial metastases from extra-thoracic neoplasms: A report of three cases and brief review of literature.

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Figure 2. (a) Protruding polypoid formation in the right upper lobar apical bronchus (black arrow) (endo-bronchial metastasis of renal cell carcinoma). (b) Axial slice in lung parenchyma
Published Dec 1, 2024
https://doi.org/10.62438/tunismed.v102i12.5202
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Vol. 102 No. 12 (2024): Tunis Med dec 2024

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Soumaya Debiche
Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia
Houda Snene
Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia
Bochra Bouchabou
Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia
Monia Attia
Department of Radiology,Mongi Slim La Marsa University Hospital,Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Hana Blibech
Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Aïda Ayadi
Department of Pathology Anatomy, Abderrahmen Mami University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Ariana, Tunisia
Rym Ennaifer
Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia
Leila Ben Farhat
Department of Radiology,Mongi Slim La Marsa University Hospital,Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Nadia Mehiri
Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia
Bechir Louzir
Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

Abstract

 


Introduction: Endobronchial metastases (EBMs) are rare, with primary tumours predominantly of breast, renal, and colorectal origin. Bronchoscopy is the diagnostic gold standard, with histological confirmation through immunohistochemical study.


Cases: We presented three cases of EBMs, one secondary to colorectal cancer and two associated with renal tumours. EBM unveiled the extra-thoracic neoplasm in colorectal cancer and was incidentally discovered during renal cancer follow-up. Bronchoscopy revealed an obstructive endobronchial mass in two cases. Histological diagnosis was established via bronchial biopsies (collecting duct renal carcinoma), computed tomography-guided transparietal lung biopsy (clear cell renal carcinoma), and endobronchial mass resection through rigid bronchoscopy (colorectal adenocarcinoma).


Conclusion: In case of an endobronchial lesion, the diagnosis of EBM should be evoked especially when the medical history reports extra-thoracic neoplasms. This diagnostic hypothesis guides the histological diagnosis and leads to an appropriate treatment.

Keywords:

Bronchoscopy, Case report, Colorectal cancer, Endobronchial, literature review, Metastasis, renal cancer

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Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biographies

Bochra Bouchabou, Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Gastrologie, Tunis, Tunisie

Hana Blibech, Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

 Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Pneumologie Allergologie, Tunis, Tunisie

Aïda Ayadi, Department of Pathology Anatomy, Abderrahmen Mami University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Ariana, Tunisia

Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Abderrahmen Mami, Service d’anatomie pathologie, Ariana, Tunisie

Rym Ennaifer, Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Gastrologie, Tunis, Tunisie

Leila Ben Farhat, Department of Radiology,Mongi Slim La Marsa University Hospital,Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de radiologie, Tunis, Tunisie

Nadia Mehiri, Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia

Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Pneumologie Allergologie, Tunis, Tunisie

Bechir Louzir, Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Pneumologie Allergologie, Tunis, Tunisie

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