Do Tunisian children with unilateral cleft lip and palate differ from normal individuals in dental maturity? A pilot study

##plugins.themes.academic_pro.article.sidebar##

Published Oct 8, 2024
https://doi.org/10.62438/tunismed.v102i10.4907
Download
pdf
Vol. 102 No. 10 (2024): Tunis Med oct 2024

##plugins.themes.academic_pro.article.main##

Manel Chalbi
Department of Pediatric Dentistry, La Rabta University Hospital, Tunis. Research Laboratory: Dento-facial biological and clinical approach LR12ES10, University of Monastir. Faculty of Dental Medicine, University of Monastir, Tunisia
Mehdi Khemiss
Department of Dental Medicine, Fattouma Bourguiba University Hospital, Monastir. Research Laboratory LR12SP10: Functional and esthetic Rehabilitation of the maxillae, Farhat HACHE University Hospital, Sousse, Tunisia. Faculty of Dental Medicine, University of Monastir, Tunisia.
Miniar Rhaiem
Department of Pediatric Dentistry, La Rabta University Hospital, Tunis. Research Laboratory: Dento-facial biological and clinical approach LR12ES10, University of Monastir. Faculty of Dental Medicine, University of Monastir, Tunisia
Nadia Elabed
Department of Pediatric Dentistry, La Rabta University Hospital, Tunis. Research Laboratory: Dento-facial biological and clinical approach LR12ES10, University of Monastir. Faculty of Dental Medicine, University of Monastir, Tunisia
Mohamed Ali Chemli
Department of Pediatric Dentistry, La Rabta University Hospital, Tunis. Research Laboratory: Dento-facial biological and clinical approach LR12ES10, University of Monastir. Faculty of Dental Medicine, University of Monastir, Tunisia

Abstract

Introduction: Cleft lip and palate (CLP) is the most common congenital malformation of the head and neck. Children with CLP often exhibit dental anomalies.


Aim: To evaluate the dental age (DA) of unilateral CLP in Tunisian children.


Methods: This was a cross-sectional study carried out in the department of pediatric dentistry at the University Hospital La Rabta, Tunis. Patients aged between 5 and 14 years, with no other congenital anomalies or syndromes in the craniofacial region other than CLP, were included. The patients’ chronological ages were first calculated in years and months. DA was assessed in panoramic radiographs using Demirjian’s method. The score of each stage is allocated, and the sum of the scores provides an evaluation of the subject’s dental maturity.


Results: Fifty-three patients were included in the present study. No difference was observed between the two groups regarding the dental age. A strong and positive correlation between the DA and the chronological age in the two groups was observed (r=0.826). Estimated regression showed that chronological age alone explained 57,4% (r2=0.574) of the dental age variation in the study group and 64.5% (r2=0.645) in the control group.


Conclusion: For dental management, CLP children should have the same approach in orthodontics and pediatric dentistry as individuals without clefts, with a focus on the individualization of diagnosis and treatment planning

Keywords:

Cleft lip. , Cleft palate, Panoramic radiographs, Tunisia

##plugins.themes.academic_pro.article.details##

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

  1. Abu-Hussein M, Watted N, Emodi O, Zere E. Role of Pediatric Dentist -Orthodontic in Cleft Lip and Cleft Palate Patients. IOSR JDMS. 2015;14(11):61-68.
  2. Worley ML, Patel KG, Kilpatrick LA. Clin Perinatol. 2018;45(4):661-678.
  3. Abulezz TA. Cleft Lip and Palate: An Experience of a Developing Center in Egypt. J Craniofac Surg. 2017;28(8):731-734.
  4. Pastuszak P, Dunin-Wilczyńska I, Lasota A. Frequency of Additional Congenital Dental Anomalies in Children with Cleft Lip, Alveolar and Palate. J Clin Med. 2020;9(12):3813.
  5. Pradhan L, Shakya P, Thapa S, Nakarmi KK, Maharjan A, Sagtani RA, Rai SM. Prevalence of Dental Anomalies in the Patient with Cleft Lip and Palate Visiting a Tertiary Care Hospital. J Nepal Med Assoc. 2020; 58(228):591-596.
  6. Babai A, Irving M. Orofacial Clefts: Genetics of Cleft Lip and Palate. Genes (Basel). 2023;14(8):1603.
  7. Cesur E, Arslan C, Münevveroğlu AP, Altuğ AT. Evaluation of Dental Age in Individuals of Different Ages with Unilateral Cleft Lip and Palate. Turk J Orthod. 2020; 33(2):103-109.
  8. Pöyry M, Nyström M, Ranta R. Tooth development in children with cleft lip and palate: a longitudinal study from birth to adolescence. Eur J Orthod. 1989; 11(2):125-130.
  9. Huyskens RW, Katsaros C, Van 't Hof MA, Kuijpers-Jagtman AM. Dental Age in Children with a Complete Unilateral Cleft Lip and Palate. Cleft Palate Craniofac J. 2006; 43(5):612-615.
  10. Topolski F, de Souza RB, Franco A, Cuoghi OA, Da Silva Assunçao LR, Fernandes A. Dental development of children and adolescents with cleft lip and palate. Braz J Oral Sci. 2014; 13(4):319-324.
  11. Salvatori O, Puri S, Tati S, Edgerton M. Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases. J Dent Res. 2016; 95(4):365-371.
  12. Demirjian A, Goldstein H, Tanner JM. A new system of dental age assessment. Hum Biol. 1973; 45(2):211-227.
  13. Kirschner RE, LaRossa D. Cleft lip and palate. Otolaryngol Clin North Am. 2000; 33(6):1191-1215.
  14. Crockett DJ, Goudy SL. Cleft lip and palate. Facial Plast Surg Clin North Am. 2014; 22(4):573-586.
  15. Al-Kharboush GH, Al-Balkhi KM, Al-Moammar K. The prevalence of specific dental anomalies in a group of Saudi cleft lip and palate patients. Saudi Dent J. 2015;27(2):75-80.
  16. Almotairy N, Pegelow M. Dental age comparison in patients born with unilateral cleft lip and palate to a control sample using Demirjian and Willems methods. Europ J Orthod. 2018; 40(1):74-81.
  17. Bindayel NA, AlSultan MA, ElHayek SO. Timing of dental development in Saudi cleft lip and palate patients. Saudi Med J. 2014; 35(3):304-308.
  18. Lai MC, King NM, Wong HM. Dental development of Chinese children with cleft lip and palate. Cleft Palate Craniofac J. 2008; 45(3):289-296.
  19. Tan ELY, Kuek MC, Wong HC, Yow M. Longitudinal dental maturation of children with complete unilateral cleft lip and palate: A case-control cohort study. Orthod Craniofac Res. 2017; 20(4):189-195.
  20. Van Dyck J, Begnoni G, Willems G, Laenen A, Thevissen P, Verdonck A, Cadenas de Llano-Pérula M. Dental development in patients with and without unilateral cleft lip and palate (UCLP): a case control study. Clin Oral Investig. 2021; 25(5):2619-2631.
  21. Ranta R. A review of tooth formation in children with cleft lip/palate. Am J Orthod Dentofacial Orthop. 1986; 90(1):11-18.
  22. Abd Rahman N, Abdullah N, Samsudin AR, Naing Mohd Ayub Sadiq L. Dental anomalies and facial profile abnormality of the non-syndromic cleft lip and palate children in kelantan. Malays J Med Sci. 2004;11(2):41-51.
  23. Carinci F, Pezzetti F, Scapoli L, Martinelli M, Avantaggiato A, Carinci P, Padula E, Baciliero U, Gombos F, Laino G, Rullo R, Cenzi R, Carls F, Tognon M. Recent developments in orofacial cleft genetics. J Craniofac Surg. 2003; 14(2):130-143.
  24. Satokata I, Maas R. Msx1-deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet. 1994; 6(4):348-356.
  25. Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y. Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002; 129(17):4135-4146.
  26. Van den Boogaard MJH, Dorland M, Beemer FA, van Amstel HK. MSX1 mutation is associated with orofacial clefting and tooth agenesis. Nat Genet. 2000; 24:342-343.
  27. Peterka M, Tvrdek M, Mullerova Z. Tooth eruption in patients with cleft lip and palate. Acta Chir Plast 1993; 35(3-4):154-158.
  28. Flores-Mir C, Rosenblatt MR, Major PW, Carey JP, Heo G. Measurement accuracy and reliability of tooth length on conventional and CBCT reconstructed panoramic radiographs. Dent Press J Orthod. 2014; 19(5):45-53.
  29. De Mulder D, Cadenas de Llano-Pérula M, Willems G, Jacobs R, Dormaar JT, Verdonck A. An optimized imaging protocol for orofacial cleft patients. Clin Exp Dent Res. 2018; 4(5):152-157.
  30. Esan TA, Yengopal V, Schepartz LA. The Demirjian versus the Willems method for dental age estimation in different populations: a meta-analysis of published studies. PLoS One. 2017; 12(11):e0186682.