Urinary tract infections in chronic kidney disease in Nephrology unit, University Hospital Center of Befelatanana, Antananarivo

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Published Jul 28, 2024
https://doi.org/10.62438/tunismed.v102i8.4830
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Vol. 102 No. 8 (2024): Tunis Med aug 2024

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Mihary Dodo
Department of Internal Medicine, Analakininina University Hospital, Toamasina, Madagascar
Faniry Notahiantsoa Ratrimoharilala
Nephrology Intensive Care Unit, Joseph Raseta Andrianavalona University Hospital, Madagascar
Benja Ramilitiana
Nephrology unit, university hospital center of Joseph Raseta Befelatanana, Antananarivo, Madagascar
Cathérine Razafindrakoto
Laboratory unit, university hospital center of Morafeno, Toamasina, Madagascar
Lova Narindra Randriamanantsoa
Nephrology intensive care unit, university hospital center of Joseph Raseta Andrianavalona
Harilalaina Willy Franck Randriamarotia
Nephrology unit, university hospital center of Joseph Raseta Befelatanana, Antananarivo, Madagascar

Abstract

Introduction: Urinary tract infection is the leading cause of nosocomial infection worldwide. It is a factor in the progression of chronic kidney disease.


Aim: To determine the epidemiological, clinical, microbiological, therapeutic and evolving profile of patients with chronic kidney disease and urinary tract infection.


Methods: This was a retrospective, descriptive study lasting 5 years, from January 2014 to december 2018 in chronic kidney disease with urinary tract infection.


Results: Fifty-one patients (7.15%) were retained with a mean age of 53.03 years and a sex ratio of 0.55. Chronic kidney disease was in end-stage in 45.1% (n=23). Cystitis was found in 49.02% (n=25) and gram-negative bacilli were found in 74.50% (n=38), predominantly


Escherichia coli (54.90%). Third generation of cephalosporins and fluoroquinolones were frequently prescribed as probabilistic antibiotics. Resistance to beta-lactam antibiotics was 50% for Escherichia coli. Factors influencing severe infection were: advanced age, male gender, urinary lithiasis, multiple antibiotic resistance and non-enterobacterial germs.


Conclusion: Urinary tract infection in chronic kidney disease were frequent and particularly severe.  

Keywords:

Antibiotic, Chronic kidney disease , Cystitis , Pyelonephritis , Sepsis , Urinary tract infection, Africa

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