Health related quality-of-life in systemic sarcoidosis in Tunisia

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Published Nov 18, 2023
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Vol. 101 No. 10 (2023): Tunis med oct 2023

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Asma Kefi
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia
Wiem Helali
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia
Khaoula Ben Abdelghani
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia
Mounira El Euch
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia
Cyrine Sassi
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia
Sami Turki
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia
Ezzeddine Abderrahim
Department of Internal Medicine A, Charles Nicolle hospital ,Tunis, Faculty of Medicine of Tunis, University ofTunis El Manar , Tunis, Tunisia

Abstract

Introduction: Sarcoidosis is a systemic granulomatosis that can be associated with large-scale physical and mental disability, affecting the health related quality-of-life (HRQoL) of patients.


Aim: To evaluate the HRQoL of tunisian patients with sarcoidosis and to identify the factors that influence it.


Methods:We conducted an analytical, cross-sectional study collecting 31 patients with sarcoidosis according to the ATS/ERS/WASOG criteria. The evaluation of the HRQoL was assessed by two questionnaires in tunisian dialect. The generic score was the Medical Outcome Study 36-Short Form Health Survey (SF-36).The specific score used was the Sarcoidosis Health Questionnaire (SHQ).


Results : The HRQoL of our 31 patients was more affected in the three domains of the SHQ compared to the SF-36, which is in favor of the better sensitivity of the SHQ to detect the influence of the extent of sarcoidosis on the HRQoL. Factors associated with more impaired HRQoLwere: age at disease onset, age at interview, comorbidities, altered spirometry results, ocular involvement, chronic cholestasis, splenic nodules, arthralgia, organ count ≥3, lymphopenia and cholestasis at the time of the interview. Taking an immunosuppressant agent, particularly Methotrexate, was associated with HRQoL improvement. The number of relapses was the most correlated factor with an altered HRQoL, and this in several domains.


Conclusion:For an effective management of patients with sarcoidosis, a bio-psycho-social approach is now necessary in order to assess the real and global impact of the disease and to improve the HRQoL of patients. Disease-specific scores seem more reliable in achieving these goals.

Keywords:

Sarcoidosis, Quality of life, Questionnaire

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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