Hyperimmunoglobulinemia E and hereditary immune deficiencies

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Published Jan 30, 2024
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Vol. 101 No. 12 (2023): Tunis Med dec 2023

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Ilham Fadil
Laboratory of Clinical Immunology, Inflammation and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Fatima Ailal
Laboratory of Clinical Immunology, Inflammation and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca. Clinical Immunology Unit, Infectious Diseases Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco
Vivien Beziat
Human Genetics of Infectious Diseases Laboratory, Necker Branch, INSERM U1163, 75015 Paris, France. Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.
Jean Laurent Casanova
Human Genetics of Infectious Diseases Laboratory, Necker Branch, INSERM U1163, 75015 Paris, France. Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.
Bertrand Boisson
Human Genetics of Infectious Diseases Laboratory, Necker Branch, INSERM U1163, 75015 Paris, France. Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.
Ahmed Aziz Bousfiha
Laboratory of Clinical Immunology, Inflammation and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca. Clinical Immunology Unit, Infectious Diseases Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco

Abstract

The detection of a high serum immunoglobulin E (IgE) level is first suggestive of allergy, atopy or parasitosis. However, some very high values can be a sign of more severe diseases. We propose a diagnostic strategy based on clinical and biological data to identify the various hereditary immune diseases that also present with abnormally high serum IgE levels.

Keywords:

Hyperimmunoglobulinemia E , Hereditary immune deficiencies , HyperIgE syndromes , Primary immune deficiencies.

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