Psychiatric disturbances in idiopathic epilepsy

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Published Nov 24, 2023
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Vol. 101 No. 11 (2023): Tunis Med nov

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Saloua Mrabet
Department of psychiatry A ,Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba Tunisia
Syrine Belguith
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Tunisia
Imen Kacem
Department of psychiatry A ,Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba , Tunisia
Yosra Zgueb
Department of psychiatry A, Razi Hospital,Manouba,Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia
Rim Jenhani
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Tunisia
Uta Ouali
Department of psychiatry A, Razi Hospital, Manouba, Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia
Amina Nasri
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia
Istabrak Abdelkefi
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Tunisia
Mouna Ben Djebara
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia
Rabaa Jomli
Department of psychiatry A, Razi Hospital,Manouba, Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia
Amina Gargouri Berrechid
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia
Riadh Gouider
Department of Neurology, LR 18SP03, Clinical Investigation Centre Neurosciences and Mental Health, Razi Hospital, Manouba, Faculty of Medicine of Tunis, university of Tunis El Manar, Tunis, Tunisia

Abstract

 


Background: The relationship between epilepsy and psychiatric disorders has been highlighted for a long time. Idiopathic epilepsy is known to have a benign course in most cases. However, the association of psychiatric disturbances could worsen the disease outcome.


Objective: we aimed to study the frequency of psychiatric symptoms in patients with idiopathic epilepsy and to assess the determinant factors in the patient group with these manifestations.


Methods: In one-year prospective study, consecutive patients diagnosed with idiopathic epilepsy were included. Those with a known psychiatric follow-up or with post ictal psychiatric disturbances were excluded. Psychiatric symptoms were evaluated with the Neurological Disorders Depression Inventory for Epilepsy, the Generalized Anxiety Disorder - 7 and the Neuropsychiatric Inventory Scale. Demographic and clinical data were collected and analyzed.


Results: Among 101 consecutive patients with idiopathic epilepsy, psychiatric symptoms were diagnosed in 61% of them. Anxiety (36.6%), psychotic features (21%) and depression (15.8 %) were the most commonly found psychiatric manifestations. Female gender (p < 10-3) and longer duration of epilepsy (p = 0.046) were significantly associated with occurrence of psychiatric disturbances. Patients under Carbamazepine and Valproic acid showed a lower frequency of depression (respectively p = 0.018 and p = 0.003).


Conclusions: Occurrence of psychiatric disturbances was frequent in idiopathic epilepsy, with psychotic manifestations and anxiety being the most common of them. Female gender and long disease course were the main determining factors of psychiatric manifestations and should be considered in management of idiopathic epilepsy.

Keywords:

epilepsy, idiopathic, psychosis, anxiety, depression, Tunisians

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