Esthesioneuroblastoma presenting as syndrome of inappropriate antidiuretic hormone secretion

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Published Nov 6, 2023
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Vol. 101 No. 8-9 (2023): Tunis med aug-sept 2023

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Ghada Saad
Department of Endocrinology, Farhat Hached Hospital, Sousse, Tunisia
Imen Halloul
Department of Endocrinology, Farhat Hached Hospital, Sousse, Tunisia
Taghrid Tlili
Department of anatomic pathology , Farhat Hached Hospital, Sousse, Tunisia
Dhia el Hak Abid
Department of Endocrinology , Farhat Hached Hospital, Sousse, Tunisia
Malika Omri
Department of Otorhinolaryngology , Farhat Hached Hospital, Sousse, Tunisia
Molka Chadli-Chaieb
Department of Endocrinology , Farhat Hached Hospital, Sousse, Tunisia

Abstract

Hyponatremia is the most common fluid electrolyte disorder in hospitalized patients. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the main cause of normovolemic hyponatremia, it can be caused by diverse etiologies: malignant tumors are the most feared cause that clinician persists in finding. Exceptionally, SIADH can complicate Esthesioneuroblastoma (ENB) or olfactory neuroblastoma, a rare tumor of the nasal sinus cavities. We report the case of a 26-year-old female patient admitted for recurrent headaches and vomiting, with a profound normovolemic hyponatremia at the initial assessment. Biological explorations have concluded in a SIADH. Imaging showed a mass of the left nasal cavity with extensions to the ipsilateral paranasal sinuses. The biopsy of the lesion, under endoscopic control, was inconclusive. The anatomopathological study, after surgical removal, concluded in ENB. The postoperative evolution was marked by the normalization of the natremia.

Keywords:

Hyponatremia, Syndrome of inappropriate antidiuretic hormone secretion, Esthesioneuroblastoma

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