Sarcopenia: a new issue in juvenile idiopathic arthritis. A study Protocol

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Published Jun 2, 2023
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Vol. 101 No. 1 (2023): Issue Jan 2023

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Hanene Lassoued Ferjani
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04
Fatma Majdoub
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04
Dorra Ben Nessib
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04
Dhia Kaffel
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04
Wafa Triki
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04
Kaouther Maatallah
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04
Wafa Hamdi
Service de rhumatologie, Institut Mohamed Kassab d’orthopédie- Manouba/ Faculté de Médecine de Tunis/ Université Tunis El Manar/ Unité de recherche UR17SP04

Abstract

Background : The decrease in muscle function and mass is defined as sarcopenia. Known for a long time as an age-related disorder, sarcopenia
is nowadays well recognized in childhood. Juvenile idiopathic arthritis (JIA), a chronic inflammatory joint disease may be associated with loss of
skeletal mass.
Objective : This protocol aims to evaluate the prevalence rate of sarcopenia and its associated factors in JIA.
Methods : To evaluate the prevalence rate and factors associated with sarcopenia in juvenile idiopathic arthritis, we are enrolling 30 children with
JIA and 30 healthy children aged between 4-and 16 years. Clinical data will report: age, sex, body mass index, disease duration, and therapeutic
management. All participants will undergo the Whole-body Dual-energy X-ray absorptiometry to assess the skeletal muscle mass. The muscle
strength will be measured using the handgrip dynamometer and adjusted to the body mass index. Data will be analyzed and compared to age and
sex reference curves.
Results : This study aims to detect sarcopenia in JIA children and identify subsequently the main associated factors. By collecting anthropometric
data and extracting the main features of the disease, specific metrics will be extracted. Body composition will be obtained using the DXA scans,
including appendicular lean mass and skeletal muscle mass. Muscle strength will also be assessed.
Conclusion : This study aims to assess sarcopenia in JIA patients, using the sarcopenia update definition. If we will provide conclusive results, it
will be possible to better identify the associated factors of sarcopenia and to prevent children from this complication.
Clinical trials registration NCT05291416

Keywords:

Sarcopenia, Juvenile Idiopathic Arthritis, Dual-energy X-ray absorptiometry

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