Primary ciliary dyskinesia associated with multiple drug intolerance syndrome: a case report

##plugins.themes.academic_pro.article.sidebar##

Published Aug 26, 2022
Download
pdf
Vol. 100 No. 12 (2022): Issue Dec.2022

##plugins.themes.academic_pro.article.main##

Naouel Guirat Dhouib
Fatma Lachtar
Fethi Ben Abdallah
Dhia Dahech
Rim Guirat
Hanène Ghozzi
Najla Bahloul
Lobna Ben Mahmoud
Zouheir Sahnoun
Khaled Zeghal

Abstract

Introduction: The term multiple drug intolerance syndrome is used for patients who express adverse drug reactions to three or more drugs
without a known immunological mechanism. It is a distinct clinical entity, different from cross-reactivity. The symptoms can range from a benign
rash to life threatening syndromes like drug reaction with eosinophilia and systemic symptoms.

Case report: We report the case of an 8-year-old child with primary ciliary dyskinesia complicated by bronchiectasis who presented multiple
drug intolerance syndrome.Through this observation; we discuss the diagnostic elements of this syndrome.

Conclusion: In the absence of validated criteria for diagnosing multiple drug intolerance syndrome, a detailed history is essential, especially
to identify the warning signs and the risk factors.

Keywords:

adverse drug reactions, antibiotics, hypersensitivity, bronchiectasis.

##plugins.themes.academic_pro.article.details##

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

  1. chiavino D, Nucera E, Roncallo C, Pollastrini E, De Pasquale T, Lombardo C, et al. Multiple-drug intolerance syndrome: clinical findings and usefulness of challenge tests. Ann Allergy Asthma Immunol. 2007 ; 99:136-42.
  2. Macy E, Ho NJ. Multiple drugintolerance syndrome : prevalence, clinicalcharacteristics, and management. Ann Allergy Asthma Immunol. 2012 ; 108(2) :88–93.
  3. Blumenthal KG, Li Y, Acker WW, Chang Y, Banerji A, Ghaznavi S, Camargo CA, Zhou L. Multiple Drug Intolerance Syndrome and Multiple Drug Allergy Syndrome: Epidemiology and Associations with Anxiety and Depression. Allergy. 2018; 73 (10):2012-23.
  4. Behera K. Sapan, Das Saibal, Chengappa G. Kavadichanda, Xavier S. Alphienes, Selvarajan Sandhiya. Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity. Curr Clin Pharmacol.2019; 14(2): 84-90.
  5. Bouguila J, Fathallah N, Tej A, Kebaili R, Ouni B, Ben Salem C ,Boughammoura L. A Challenging Case of MultipleDrug Intolerance Syndrome in a Child .Acta Scientific Paediatrics.2018; 1:1.
  6. Amsler E, Soria A. Hypersensitivity reactions to beta-lactam antibiotics. Rev Med Interne 2017 ; 38(11):737-48.
  7. The CARE Guidelines: Consensus-basedClinical Case Reporting Guideline Development. Glob Adv Health Med. 2013; 2(5):38-43.
  8. Bégaud B, Evereux JC, Jouglard J, Lagier G. Unexpected or toxic drug reaction assessment. Actualisation of the method used in France. Therapie1985 ; 40:111-8.
  9. Kuehni CE, Lucas JS. Diagnosis of primary ciliary dyskinesia: summary of the ERS task force report. Breathe.2017 ; 13(3) :2–14.
  10. Paff Tamara, O Heymut, Nielsen G K , Haarman GE .Current and Future Treatments in Primary Ciliary Dyskinesia. Int J Mol Sci. 2021;18 :9834.
  11. Lehloenya RJ, Wallace J, Todd G, Dheda K. Multiple drug hyper-sensitivity reactions to anti-tuberculosis drugs: five cases inHIV-infected patients. Int J Tuberc Lung Dis2012 ; 16:1260-4.
  12. Omer HM, Hodson J, Thomas SK, Coleman JJ. Multiple drugintol-erance syndrome : alarge-scale
  13. retrospectivestudy. Drug Saf 2014 ; 37:1037-45.
  14. De Pasquale T, Nucera E, Boccascino R, Romeo P, Biagini G, Buonomo A, et al. Allergy and psychologic evaluations of patients with multiple drug intolerance syndrome. InternEmerg Med 2012 ; 7(1) :41-7.
  15. Mayorga C, Celik G, Rouzaire P, Whitaker P, Bonadonna P, Cernadas JR, et al. In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy 2016 ; 71:1103-34.
  16. Ponvert C. Diagnostic des réactions d’hypersensibilité allergique et non allergique aux médicaments courants de l’enfant : arbre décisionnel. Arch Pediatr 2011 ; 18 (4) :486-92.
  17. Waton J, Pouget-Jasson C, Loos-Ayav C, et al. Drug rechallenges in cutaneous adverse drug reactions: information and effectiveness in the long-term management of patients. Allergy. 2011 ; 66:941–7.