East-central Tunisian patients with colorectal adenocarcinoma: a comparative study of the clinicopathological features between patients under 50 years of age and older patients

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Published Jul 8, 2022
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Vol. 100 No. 7 (2022): Issue Jul 2022

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Mohamed Salah Jarrar
Malek Barka
Mohamed Zied Ben Abdessalem
Radhouane Toumi
Soumaya Mrabet
Nihed Abdessayed
Mohamed Hedi Mraidha
Asma Sghaier
Fehmi Hamila
Sabri Youssef

Abstract

Introduction: Colorectal cancer is a major public health problem. In younger patients, its incidence continues to rise and its prognosis appears to
be worse. Its treatment is based on curative surgery associated with neo-adjuvant and adjuvant therapies.

Aim: To describe the clinical and pathological characteristics of colorectal cancers in young patients.

Methods: In this monocentric cohort study, we retrospectively analyzed the clinicopathological features in colorectal cancer patients who underwent
treatment from 2002 to 2014. Data of younger (group A, ≤50years) vs older (group B, >50years) patients were compared.

Results: Two hundred and sixty-six patients met inclusion and non-inclusion criteria. The younger and older groups consisted respectively of
25.2% and 74.8% of patients. Both groups were comparable regarding the symptom presentation and duration. Synchronous tumors were more
frequent amongst the group A (10.7% vs 1.0%, p = 0.024). Preoperative staging showed a higher frequency of tumors classified as advanced
stage (stages III and IV) in the group A (p = 0.001). The patients of group A were diagnosed with a higher proportion of poorly differentiated or
undifferentiated adenocarcinomas (13.4% vs 3.5%, p = 0.005), the mucinous character was also more frequent in the group A (28.4%). According
to the pTNM (tumor, nodes and metastases) classification, tumors were more advanced in the group A than in group B (80.6% vs 48.7%, p < 0.001),

Conclusion: This study revealed that colorectal adenocarcinomas in the younger patients, compared to the older ones, were more aggressive
with a higher proportion of poorly differentiated or undifferentiated adenocarcinomas, more often mucin production and more advanced tumors.

Keywords:

Colorectal cancer - Young patients - Prognosis - Early onset

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