Influence of homocysteine and its major genetic and nutritional determinants on bone mineral density

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Published Jul 5, 2022
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Vol. 100 No. 7 (2022): Issue Jul 2022

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Aissam El Maataoui
Kaoutar Idouz
Abdellah El Maghraoui
Selama Nadifi
Zohra Ouzzif

Abstract

Introduction: A potential role of hyperhomocysteinemia in bone metabolism has been considered from the observation of high prevalence of osteoporosis in
subjects with homocystinuria about 50 years ago.

Aim: To examine the association of homocysteine level and its determinants Methylenetetrahydrofolate Reductase [MTHFR] C677T Polymorphism, folates and
vitamin B12 levels with bone mineral density [BMD] and the prevalence of vertebral fractures [VF] on postmenopausal women.

Methods: Through a cross-sectional study, one hundred and twenty-two healthy postmenopausal women gave their informed consent to participate in this study.
Women were recruited through advertisements and mouth to ear between January 2017 and May 2017. One serum tube and one EDTA tube were collected
from fasting patients. Bone mineral density was determined by a Lunar Prodigy® Vision DXA system®. Vertebral fracture [VF] assessment image was inspected
visually by 2 clinicians.

Results: We found that a high level of homocysteine and low vitamin B12 and folate levels are not associated with bone mineral density and are not risk factors for
VF in healthy postmenopausal women. Whereas, the presence of VF was associated with the number of years since menopause and with the osteocalcin levels.

Conclusion: The MTHFR C677T polymorphism, the high levels of HCY, or low levels of folate and vitamin B12 would not be risk factors for osteoporosis and VF
in healthy postmenopausal women.

Keywords:

Homocysteine - Methylenetetrahydrofolate Reductase C677T polymorphism - Bone mineral density - Vertebral Fracture.

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