Characterization of a cluster of COVID-19 cases linked to the Omicron variant, in Mauritania

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Sidi Mohamed Laghdaf
Ahmed El Baraa
Alia Mohamed Beydjeu

Abstract

Objective: To describe the epidemiological and genomic profile of COVID-19 during the 4th epidemic wave in Mauritania.

Methods: This is a cross-sectional study in Mauritania, from October 1, 2021 to February 28, 2022. Were included all people in the process
of travel, performing an RT-PCR, at the level of the National Research Institute in Public Health and patients who have been sampled for
sequencing by teams from the Department of Strategic Information and Epidemiological Surveillance.

Results: Out of 37,574 RT-PCR tests collected on March 3, 2022, during the study period, 1,465 cases were diagnosed positive for COVID-19
(3.9%), with an average age of 39±14,6 years and a sex ratio of 2.08. Of the 112 genomic sequences performed, 75 were of the Omicron
variant (66.9%). The average age was 40±15 years, with extremes of 15 to 82 years and a sex ratio of 0.97. The vaccination status was
assured in 67.7% of patients and the peak of the Omicron variant was reached during the first week of January 2022

Conclusion: The Omicron variant was predominant during the 4th wave in Mauritania. As part of its response plan against COVID-19, the installation
of new sequencing units inside the country and the strengthening of the training of technicians in the virology laboratory will be essential.


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References

  1. Coronavirus Internet . cité 19 mars 2022 . Disponible sur:https://www.who.int/fr/health-topics/health-systemsgovernance
  2. Mousavizadeh L, Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. J Microbiol Immunol Infect. avr 2021;54(2):159-63.
  3. Hassanin AA, Haidar Abbas Raza S, Ahmed Ujjan J, Aysh Al-rashidi A, Sitohy BM, Al-surhanee AA, et al. Emergence, evolution, and vaccine production approaches of SARSCoV-2 virus: Benefits of getting vaccinated and common questions. Saudi J Biol Sci Internet . 13 déc 2021 cité 19 mars 2022 ; Disponible sur: https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8667566/
  4. Mekolo D, Bokalli FA, Chi FM, Fonkou SB, Takere MM, Ekukole CM, et al. Clinical and epidemiological characteristics and outcomes of patients hospitalized for COVID-19 in Douala, Cameroon. Pan Afr Med J. 2021; 38: 246.
  5. Koyama T, Weeraratne D, Snowdon JL, Parida L. Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment. Pathogens. 26 avr 2020;9(5):E324.
  6. Jamai Amir I, Lebar Z, Yahyaoui G, Mahmoud M. Covid-19 : virologie, épidémiologie et diagnostic biologique. Option/Bio. juill 2020;31(619-620):15-20.
  7. El Vally A, Bollahi MA, Ould Ahmedou Salem MS, Deida J, Parola P, Basco L, et al. Retrospective overview of a COVID-19 outbreak in Mauritania. New Microbes New Infect. Nov 2020;38:100788.
  8. Chen M, Li M, Hao Y, Liu Z, Hu L, Wang L. The introduction of population migration to Seiar for COVID-19 epidemic modeling with an efficient intervention strategy. Informat Fusion. dec 2020;64:252-8.
  9. Wang C, Liu Z, Chen Z, Huang X, Xu M, He T, et al. The establishment of reference sequence for SARS-CoV-2 and variation analysis. J Med Virol. Juin 2020;92(6):667-74.
  10. Aleem A, Akbar Samad AB, Slenker AK. Emerging Variants of SARS-CoV-2 And Novel Therapeutics Against Coronavirus (COVID-19). In: Stat Pearls Internet . Treasure Island (FL): Stat Pearls Publishing; 2022 cité 19 mars 2022 . Disponible sur: http://www.ncbi.nlm.nih.gov/books/NBK570580/
  11. Poterico JA, Mestanza O. Genetic variants and source of introduction of SARS-CoV-2 in South America. J Med Virol. oct 2020;92(10):2139-45.
  12. Tracking SARS-CoV-2 variants Internet . cité 19 mars 2022 . Disponible sur: https://www.who.int/en/activities/ tracking-SARS-CoV-2-variants
  13. Gu H, Krishnan P, Ng DYM, Chang LDJ, Liu GYZ, Cheng SSM, et al. Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, China, Nov 2021 - Vol 28, Number 2—February 2022 - Emerg Infect Dis J - CDC. cité 19 mars 2022 ; Disponible sur: https://wwwnc. cdc.gov/eid/article/28/2/21-2422_article
  14. Chen J, Wang R, Gilby NB, Wei G-W. Omicron (B.1.1.529): Infectivity, vaccine breakthrough, and antibody resistance. ArXiv. 1 déc 2021;arXiv:2112.01318v1.
  15. Ahmed MLCB, Zehaf S, El Alem MM, Elbara A, Ely Mahmoud MM, Mohamed Abdellahi MV, et al. COVID-19 outbreak in Mauritania: epidemiology and health system response. J Infect Dev Countries. Août 2021;15(08):1048-53.
  16. Torres I, Poujois S, Albert E, Colomina J, Navarro D. Evaluation of a rapid antigen test (PanbioTM COVID-19 Ag rapid test device) for SARS-CoV-2 detection in asymptomatic close contacts of COVID-19 patients. Clin Microbiol Infect. Avr 2021;27(4):636.e1-636.e4.
  17. Diawara I, Benrahma H, Nida M, Rahoui J, Moujid F-Z, Jaras K, et al. A laboratory-based study of COVID-19 in Casablanca, Morocco. J Public Health Afr. 31 déc 2021;12(2):1458.
  18. Abdullah F, Myers J, Basu D, Tintinger G, Ueckermann V, Mathebula M, et al. Decreased severity of disease during the first global Omicron variant covid-19 outbreak in a large hospital in tshwane, south africa. Int J Infect Dis. 1 mars 2022;116:38-42.
  19. Kenu E, Odikro MA, Malm KL, Asiedu-Bekoe F, Frimpong JA, Calys-Tagoe B, et al. Epidemiology of COVID-19 outbreak in Ghana, 2020. Ghana Med J. 2020 Dec; 54(4 Suppl): 5–15..
  20. Wang Y, Liu Y, Liu L, Wang X, Luo N, Ling L. Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China. J Infect Dis. 2020 Mar 17 : jiaa119.
  21. Boushab BM, Koné N, Baba SWO, El Mokhtar B, Mohamed JOM, Ahmed MMO, Habiboullah HO, et al. Management of COVID-19 infection in patients undergoing hemodialysis. Pan Afr Med J 2021;38:13.
  22. Krishnan A, Hamilton JP, Alqahtani SA, A.Woreta T. A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations. Intern Emerg Med. juin 2021;16(4):815-30.
  23. Boushab B, Fall-Malick F, Kelly M, Ould Ahmed Baba E, Ould Sidi Mohamed O, Ould Baba S, et al. Caractéristiques épidémio-cliniques, biologiques et radiologiques des adultes atteints de COVID-19 au centre hospitalier de Kiffa, Assaba (Mauritanie). Rev Mali Infect Microbiol. 31 janv 2021;16(1):25-31.
  24. Achour H, Mokrani D, Yakoub F. Contribution à l’étude épidémiologique de la Covid-19 dans la région de Mémoire de Master . Biskra: Faculté des sciences exactes et des sciences de la nature et de la vie Département des sciences de la nature et de la vie. Université Mohamed Khider de Biskra, 2021.
  25. Update-of-SA-sequencing-data-from-GISAID-17-Dec-21_ Final.pdf Internet . cité 25 mars 2022 . Disponible sur: https://www.nicd.ac.za/wp-content/uploads/2021/12/ Update-of-SA-sequencing-data-from-GISAID-17-Dec-21_ Final.pdf
  26. Brandal LT, MacDonald E, Veneti L, Ravlo T, Lange H, Naseer U, et al. Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021. Eurosurveillance Internet . 16 déc 2021 cité 19 mars 2022 ;26(50). Disponible sur: https://www.eurosurveillance. org/content/10.2807/1560-7917.ES.2021.26.50.2101147
  27. Maisa A, Spaccaferri G, Fournier L, Schaeffer J, Deniau J, Rolland P, et al. First cases of Omicron in France are exhibiting mild symptoms, November 2021–January 2022. Infect Dis Now Internet . 12 févr 2022 cité 23 mars 2022 ; Disponible sur: https://www.sciencedirect.com/science/ article/pii/S2666991922000367
  28. Espenhain L, Funk T, Overvad M, Edslev SM, Fonager J, Ingham AC, et al. Epidemiological characterisation of the first 785 SARS- CoV-2 Omicron variant cases in Denmark, December 2021. Euro Surveill; 26(50)2021 12.
  29. Jassat W, Karim SA, Mudara C, Welch R, Ozougwu L, Groome M, et al. Clinical Severity of COVID-19 Patients Admitted to Hospitals in Gauteng, South Africa During the Omicron-Dominant Fourth Wave. SSRN J Internet . 2021 cité 20 mars 2022 ; Disponible sur: https://www.ssrn.com/ abstract=3996320
  30. Kim M-K, Lee B, Choi YY, Um J, Lee K-S, Sung HK, et al. Clinical Characteristics of 40 Patients Infected With the SARS-CoV-2 Omicron Variant in Korea. J Korean Med Science Internet . 7 déc 2021 cité 26 mars 2022 ;37(3). Disponible sur: https://doi.org/10.3346/jkms.2022.37.e31
  31. Padane A, Mbow M, Mboup A, Diedhiou CK, Gueye K, Lo CI, et al. Rapidly rising cases with Omicron in Senegal. New Microbes New Infect. 1 janv 2022;45:100959.