An isolated spontaneous pneumomedistinum as a rare complication of COVID 19

##plugins.themes.academic_pro.article.main##

Nadia Moussa
Rahma Gargouri
Yosser Henteti
Amal Saidani
Nesrin Kallel
Jihen Hadj Kacem
Amina kotti
Zeineb Mnif
Samy Kamoun

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic has displayed heterogeneity in disease manifestations and complications. This case report illustrates a rare issue : the spontaneous pneumomediastinum.
A 73-year-old male presented with chills, and respiratory symptoms. A reverse transcriptase polymerase chain reaction (RT-PCR) test- confirmed COVID19. At admission, the patient was in severe respiratory distress. C reactive protein was 54 mg/l (normal: 0-5 mg/l), , troponin were negative, brain natriuretic peptid 55 pg/ml (normal range <100 pg/ml) and D-dimer 700 mcg/l (normal: 0-500 mcg/l). Arterial blood gases showed pH 7.49 (normal: 7.35-7.45), PCO2 33,8 mmHg (normal: 34-46 mmHg) and PO2 56 mmHg (normal: 80-97 mmHg) with 16 liter per minute of oxygen. Computed tomography of the chest (CT chest) showed diffuse groundglass opacities (60-70%) without pulmonary embolism. Diagnosis of acute respiratory distress syndrome (ARDS) was made. Low flow oxygen was provided (Oxygen saturation target ≥ 94%), intermediate dose of low molecular weight heparin and 8mg of dexamethason were administarted daily. On day 10, worsening hemodynamics and blood oxygen levels was noted. CT chest showed moderate bilateral pneumomediastinum, without pneumothorax, persistent groundglass opacities (75%) with early fibrosis elements. The patient recovered with no pulmonary sequelae.
This case report encourages health workers to get used with infrequent clinical and radiological manifestations of COVID-19 that is still surprising the world.

Keywords:

COVID-19, spontaneous pneumomediastinum, acute respiratory distress, COVID-19 complications

##plugins.themes.academic_pro.article.details##

References

  1. 1. Moses Hayrabedian Rajagopal Sreedhar, Faraaz Nayeemuddin. Pneumomediastinum in a critically ill coronavirus disease 2019 (covid-19) patient. Chest Annual Meeting. (2020) 2. R. Bhat, A. Hamid, J. Kunin, et al., [Ahead of print]. Chest imaging in patients hospitalized with COVID-19 infection - a case series, Curr. Probl. Diagn. Radiol. (2020), https://doi.org/10.1067/j.cpradiol.2020.04.001 3. X. Yang, Y. Yu, J. Xu, et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respir Med 8 (5) (2020) 475-481, https://doi.org/10.1016/S2213-2600(20)30079-5. 4. R.D. Marasco, D. Loizzi, N.P. Ardo, F.N. Fatone, F. Sollitto, Spontaneous pneumomediastinum after electronic cigarette use, Ann. Thorac. Surg. 105 (2018) e269-271, https://doi.org/10.1016/j.athoracsur.2017.12.037 5. S. Murayama, S. Gibo, Spontaneous pneumomediastinum and Macklin effect: overview and appearance on computed tomography, World J. Radiol. 6 (11) (2014) 850-854, https://doi.org/10.4329/wjr.v6.i11.850. 6 . M.T. Macklin, C.C. Macklin, Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: an interpretation of the clinical literature in the light of laboratory experiment, Medicine 23 (4) (1944) 281-358 7. R.J. Mason, Pathogenesis of COVID-19 from a cell biologic perspective, Eur. Respir. J. 55 (4) (2020) 2000607, https://doi.org/10.1183/13993003.00607-2020. 8. Silvana Di Maio, MD*,1, Antonio Esposito, MDy, Albero Margonato, MD*, Cosmo Godino, MD* Massive Spontaneous Subcutaneous Emphysema and Pneumomediastinum as Rare Complications of COVID-19 Pneumonia. Journal of cardiothoracic and vascular anesthesia. 1053-0770 (2021), https://doi.org/10.1053/j.jvca.2021.03.002