Bilateral Diffuse Uveal Melanocytic Proliferation: Report Of A Rare Ocular Paraneoplastic Syndrome

##plugins.themes.academic_pro.article.main##

Mejdi Boukari
Imen Zhioua Braham
Héla Kaouel
Maroua Anane
Imen Ammous
Raja Zhioua

Abstract

Bilateral diffuse uveal melanocytic proliferation is a rare paraneoplastic disorder where bilateral blindness is caused by uveal thickening, serous retinal detachment, and rapid cataract formation.
Several different malignancies have been associated with bilateral diffuse uveal melanocytic proliferation, but ovarian carcinoma in women and lung and pancreatic carcinoma in men are the most common.
The underlying mechanism is thought to be related to a an endogenous factor wich regulates the proliferation of uveal melanocytes.
We present the case of a 75-year-old man with bilateral diffuse uveal melanocytic proliferation secondary to pulmonary adenocarcinoma.

Keywords:

Bilateral diffuse uveal melanocytic proliferation - Melanocytes - Malignancy - Paraneoplastic retinopathy

##plugins.themes.academic_pro.article.details##

References

  1. References : 1) Gass JDM, Gieser RG, Wilkinson CP, Beahm DE, Pautler SE. Bilateral diffuse uveal melanocytic proliferation in patients with occult carcinoma. Arch Ophthalmol 1990;110:49-56. 2) O'Neal KD, Butnor KJ, Perkinson KR, Proia AD. Bilateral diffuse uveal melanocytic proliferation associated with pancreatic carcinoma: a case report and literature review of this paraneoplastic syndrome. Surv Ophthalmol. 2003;48(6):613-625. 3) Joseph A, Rahimy E, Sarraf D. Bilateral diffuse uveal melanocytic proliferation with multiple iris cysts. JAMA Ophthalmol. 2014 Jun;132(6): 756-60. 4) Rahimy E, Coffee R, and McCannel T. Bilateral Diffuse Uveal Melanocytic Proliferation as a Precursor to Multiple Systemic Malignancies. Seminars in Ophthalmology, 2015; 30(3): 206-209. 5) Ling CP, Pavesio C. Paraneoplastic syndromes associated with visual loss. Curr Opin Ophthalmol 2003;14:426e32. 6) Miles SL, Niles RM, Pittock S, et al. A factor found in the IgG fraction of patients with paraneoplastic bilateral diffuse uve-al melanocytic proliferation causes proliferation of cultured human melanocytes. Retina 2012;32:1959-66. 7) Moreno TA, Patel SN. Comprehensive Review of Treatments for Bilateral Diffuse Uveal Melanocytic Proliferation: A Focus on Plasmaphereis. Int Ophthalmol Clin. 2017 Winter;57(1):177-194.