Lipid and oxidative profile in hemodialysis patients: Clinical follow-up for three years.

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Published Oct 4, 2019
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Vol. 97 No. 4 (2019): Issue Apr 2019

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Olfa Ben Omrane Sioud
Zohra El Ati
Hassan Bouzidi
Mohsen Kerkeni
Mohamed Hammami

Abstract

Background: The major cause of death for hemodialysis (HD) patients was cardiovascular morbidity; it was closely related to oxidative stress (OS).
Aim: Firstly, to evaluate lipid peroxidation biomarkers on HD patients through measuring malondialdehyde (MDA) and conjugated dienes (CD), and secondly, to follow these parameters after three years undergoing HD.
Methods: One hundred patients with end stage renal diseases receiving regular hemodialysis and 100 healthy volunteers were included in this study. Routine chemical data, lipid profile and levels of MDA and CD were measured.
Results: The plasmatic and erythrocyte MDA levels were significantly increased in the HD patients compared to healthy subjects (p <0.001). However, an increased level on erythrocyte CD was only observed between the two study groups (p<0.001). After 3 years, a significant increased level of lipid peroxidation biomarkers was observed.
Conclusion: The disturbance in lipid peroxidation state in HD patients was observed. At three years follow-up, oxidative stress is more pronounced with a significant increase in MDA and CD.

Keywords:

Oxidative stress; lipid peroxidation; malondialdehyde; conjugated dienes; hemodialysis patients

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