Contribution of imaging in the management of resistant tuberculosis
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Abstract
Introduction: Resistant tuberculosis is a topical subject given the difficulties of its management.
Objective: To evaluate the role of imaging in the diagnosis and follow-up of multidrug-resistant tuberculosis (MDR-TB).
Methods: Retrospective study of MDR-TB cases followed in Hall C of Abderrahmane Mami Hospital (2010 to 2016).
Results: Forty four patients included. The average age was 33 (15-58). The sex ratio was 1.7. Chest radiographs at the start of treatment showed lesions dominated by nodules (n = 39) and cavities (n = 36). The parenchymal lesions were bilateral (n = 32), associated pleural (n = 4) and mediastinal lesions (n = 7). During treatment, radiological improvement dominated during the first 7 months of treatment. Computed tomography was performed as part of the preoperative assessment of MDR-TB (n = 2), lung cancer extension assessment (n = 1) and etiological assessment of haemoptysis. It allowed to refute a suspected pulmonary embolism (n = 1) and to drain a pleural effusion. Parenchymal lesions on CT were dominated by nodules (n = 8) and cavities (n = 6). Mediastinal nodes (n = 4) and pleural effusions (n = 3) were noted. Ultrasonography showed pleural effusion with pleural thickening (n = 2) and permits its ponction.
Conclusion: Imaging is a key element in the diagnostic approach to tuberculosis. It permits to evaluate tuberculous lesions and to detect tuberculous complications. It helps to guide the therapeutic management and evaluate its effectiveness.
Keywords:
imaging, scanner, mycobacterium tuberculosis, resistant tuberculosis, treatment##plugins.themes.academic_pro.article.details##
References
- Organization WH, others. Global tuberculosis report 2016. 2016; Available from: http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf
- Tritar F, Daghfous H, Ben Saad S, Slim-Saidi L. Prise en charge de la tuberculose multirésistante. Revue de Pneumologie Clinique 2015;71:130-9.
- Campbell IA, Bah-Sow O. Pulmonary tuberculosis: diagnosis and treatment. BMJ. 2006;332(7551):1194-7.
- Hantous-Zannad S, Zidi A, Néji H, Attia M, Baccouche I, Miled-M'rad K. Apport de l'imagerie dans la tuberculose thoracique. Rev Pneumol clin. 2015; 71: 93-109.
- Song Q, Zhang G, Jiang H, Ren Y, Lu X. Imaging Features of Pulmonary CT in Type 2 Diabetic Patients with Multidrug-Resistant Tuberculosis. PloS One. 2016;11(3):e0152507.
- Zhang L, Pang Y, Yu X, Wang Y, Lu J, Gao M, et al. Risk factors for pulmonary cavitation in tuberculosis patients from China. Emerg Microbes Infect. 2016;5(10):e110.
- Chuchottaworn C, Thanachartwet V, Sangsayunh P, Than TZM, Sahassananda D, Surabotsophon M, et al. Risk Factors for Multidrug-Resistant Tuberculosis among Patients with Pulmonary Tuberculosis at the Central Chest Institute of Thailand. PloS One. 2015;10(10):e0139986.
- Heo EY, Chun EJ, Lee CH, Kim YW, Han SK, Shim Y-S, et al. Radiographic improvement and its predictors in patients with pulmonary tuberculosis. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2009;13(6):e371-376.
- Cha J, Lee HY, Lee KS, Koh W-J, Kwon OJ, Yi CA, et al. Radiological findings of extensively drug-resistant pulmonary tuberculosis in non-AIDS adults: comparisons with findings of multidrug-resistant and drug-sensitive tuberculosis. Korean J Radiol. 2009;10(3):207-16.
- Brust JCM, Berman AR, Zalta B, Haramati LB, Ning Y, Heo M, et al. Chest radiograph findings and time to culture conversion in patients with multidrug-resistant tuberculosis and HIV in Tugela Ferry, South Africa. PloS One. 2013;8(9):e73975.
- Shin SS, Keshavjee S, Gelmanova IY, Atwood S, Franke MF, Mishustin SP, et al. Development of extensively drug-resistant tuberculosis during multidrug-resistant tuberculosis treatment. Am J Respir Crit Care Med. 2010;182(3):426-32.
- Das SK, Das A, Gangopadhyay A, Sinha AK. Primary disseminated extrapulmonary multidrug resistant tuberculosis. Indian J Med Microbiol. 2012;30(3):364-6.
- Jihoon C, Ho Yun L, Kyung L, Won-Jung K, Jung K, Chin A and al. Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults: Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis. Korean J Radiol. 2009;10(3): 207-16.
- Madansein R, Parida S, Padayatchi N, Singh N, Master I, Naidu K, Zumla A, Maeurer M. Surgical treatment of complications of pulmonary tuberculosis, including drug-resistant tuberculosis. Int J Infect Dis. 2015;32:61-7.
- Ben Amar J, Dahri B, Aouina H, Bouacha H. Maladie veineuse thromboembolique au cours de la tuberculose. Rev Pneumol Clin. 2015;71(6):327-34.
- Chen RY, Dodd LE, Lee M, Paripati P, Hammoud DA, Mountz JM, et al. PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis. Sci Transl Med. 2014;6(265):265ra166.
- Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, et al. PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis. Sci Transl Med. 2014;6(265):265ra167.