Presumed Tuberculous uveitis: clinical features and management.
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Abstract
Aim: To illustrate the various clinical features and management of presumed tuberculous uveitis in an endemic area in Tunisia.
Methods: This is a retrospective study including 14 patients (26 eyes) diagnosed with presumed tuberculous uveitis at the Department of Ophthalmology Habib Bourguiba University Hospital of Sfax-Tunisia.
Results: Mean age at onset was 31.7 years. Uveitis was bilateral in 86 % of cases (12 eyes). Panuveitis was the most common manifestation and represented 50% of cases (13 eyes). Ocular findings include mutton-fat keratic precipitates in 35% of cases (9 eyes), posterior synechiae in 31% of cases (8 eyes), vitritis in 81% of cases (21eyes), multifocal choroiditis in 23% of cases (6 eyes), periphlebitis in 27% of cases (7 eyes), and macular edema in 42% of cases (11eyes). Anti-tubercular treatment was prescribed in all patients and was associated with systemic corticosteroids in 71% of cases (10 patients). After a mean follow-up of 16.27 months (range, 6-36), inflammation was controlled with improvement in visual acuity. Recurrence developed in 7 % of cases (1 patient).
Conclusion: In the present study, posterior synechiae, vitritis, multifocal choroiditis, and retinal vasculitis are the most common manifestations of tuberculous uveitis in tuberculosis endemic area in Tunisia. These manifestations are suggestive of a tubercular cause of uveitis and merit specific treatment.
Keywords:
Uveitis ; Tuberculosis ; Retinal vasculitis ; Choroiditis.##plugins.themes.academic_pro.article.details##
References
- Gupta V, Gupta A, Rao NA. Intraocular Tuberculosis-an Update. Surv Ophthalmol 2007; 52 (6):561-87.
- Al-Mezaine HS, Kangave D, Abu El-Asrar AM. Patterns of uveitis in patients admitted to a University Hospital in Riyadh, Saudi Arabia. Ocul Immunol Inflamm 2010;18(6):424-31.
- Singh R, Gupta V, Gupta A. Pattern of uveitis in a referral eye clinic in north India. Indian J Ophthalmol 2004;52:121- 5.
- Wakabayashi T, Morimura Y, Miyamoto Y, Okada AA.Changing patterns of intraocular inflammatory disease in Japan. Ocul Immunol Inflamm 2003; 11: 277-286.
- Henderly DE, Genstler AJ, Smith RE, Rao NA. Changing patterns of uveitis. Am J Ophthalmol 1987; 103: 131-6.
- Khairallah M, Yahia SB, Ladjimi A et al. Pattern of uveitis in a referral centre in Tunisia, North Africa. Eye 2007;21:33-9.
- Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitisnomenclature for reporting clinical data. Results of the First InternationalWorkshop. Am J Ophthalmol 2005; 140 (3):509-16.
- Ang M, Hedayatfar A,WongW, Chee SP. Duration of anti-tubercular therapy in uveitis associated with latent tuberculosis: a case-control study. Br J Ophthalmol 2012; 96:332-6.
- Gupta A, Bansal R, Gupta V, Sharma A, Bambery P. Ocular signs predictive of tubercular uveitis. Am J Ophthalmol 2010;149(4):562-70.
- Sanghvi C, Bell C, Woodhead M, Hardy C, Jones N. Presumed tuberculous uveitis: diagnosis, management, and outcome. Eye 2011;25(4):475-80.
- Cimino L, Herbort CP, Aldigeri R, Salvarani C, Boiardi L. Tuberculous uveitis, a resurgent and underdiagnosed disease. Int Ophthalmol 2009;29(2):67-74.
- Varma D, Anand S, Reddy AR et al. Tuberculosis: an under-diagnosed aetiological agent in uveitis with an effective treatment. Eye 2006;20(9):1068-73.
- Ang M, Htoon HM, Chee S-P. Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. Ophthalmology 2009;116(7):1391-6.
- Agrawal R, Gonzalez-Lopez JJ, Nobre-Cardoso J et al. Predictive factors for treatment failure in patients with presumed ocular tuberculosis in an area of low endemic prevalence. Br J Ophthalmol 2016 Mar;100(3):348-55.
- Tabbara KF. Ocular tuberculosis: anterior segment. Int Ophthalmol Clin 2005;45(2):57-69.
- Alvarez GG, Roth VR, Hodge W. Ocular tuberculosis: diagnostic and treatment challenges. Int J Infect Dis 2009;13(4):432-5.
- Khochtali S, Gargouri S, Abroug N et al. The spectrum of presumed tubercular uveitis in Tunisia, North Africa. Int Ophthalmol 2015;35(5):663-71.
- Hamade IH, Tabbara KF. Complications of presumed ocular tuberculosis.Acta Ophthalmol 2010; 88(8):905-9.
- Zhang M, Zhang J, Liu Y. Clinical presentations and therapeutic effect of presumed choroidal tuberculosis. Retina 2012;32(4):805-13.
- Mehta S. Fundus fluorescein angiography of choroidal tubercles:Case reports aand review of literature. Indian J Ophthalmol 2006, 54 : 273-5.
- Mehta S. Ocular lesions in acute disseminated tuberculosis. Ocul Immunol Inflamm 2004;12(4):311-5.
- Gupta V, Gupta A, Arora S, Bambery P, Dogra MR, Agarwal A. Presumed tubercular serpiginouslike choroiditis: clinical presentations and management. Ophthalmology 2003; 110(9):1744-9.
- Gupta A, Gupta V, Arora S, et al. PCR-positive tubercular retinal vasculitis: clinical characteristics and management. Retina 2001; 21(5):435-44.
- Biswas J, Sharma T, Gopal L et al. Eales disease-an update. Surv Ophthalmol 2002, 47: 197-214.
- Abu El Asrar AM, Al-kharashi SA. Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). Br J Ophthalmol 2002, 86 : 1248-51.
- Al-Mezaine HS, Al-Muammar A, Kangave D, Abu El-Asrar AM. Clinical and optical coherence tomographic findings and outcome of treatment in patients with presumed tuberculous uveitis. Int Ophthalmol 2008; 28(6):413-23.
- Babu K, Kini R, Mehta R, Philips M, Subbakrishna DK, Murthy KR. Predictors for tubercular uveitis: a comparison between biopsy-proven cases of tubercular and sarcoid uveitis. Retina 2012; 32:1017-20.
- Bansal R, Gupta A, Gupta V, Dogra MR, Bambery P, Arora SK. Role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis. Am J Ophthalmol 2008;146:772-9.
- Abu El-Asrar AM, Al-Mezaine HS. Anti-tuberculous therapy combined with systemic corticosteroids improves retinal sensitivity in patients with active presumed tuberculous choroiditis. Int Ophthalmol 2010; 30(5):567-76.
- Bansal R, Gupta A, Gupta V, Dogra MR, Sharma A, Bambery P. Tubercular serpiginous-like choroiditis presenting as multifocal serpiginoid choroiditis. Ophthalmology 2012; 119:2334-42.
- Basu S, Das T. Pitfalls in the management of TBassociated uveitis. Eye 2010; 24:1681-4.
- Rosen PH, Spalton DJ, Graham EM. Intraocular tuberculosis. Eye 1990; 4:486-92.
- Lou SM, Montgomery PA, Larkin KL, Winthrop K, Zierhut M, Rosenbaum JT. Uveitis Specialists Study Group. Diagnosis and Treatment for Ocular Tuberculosis among Uveitis Specialists: The International Perspective. Ocul Immunol Inflamm 2015 ;23:32-9.
- Gupta V, Gupta A, Sachdeva N, Arora S, Bambery P. Successful Management of Tubercular Subretinal Granulomas. Ocul Immunol Inflamm 2006 ; 14:35-40.
- Ang M, Wanling W, Chee SP. Clinical significance of an equivocal interferon c release assay result. Br J Ophthalmol 2012;96:284-8.