Primary Immunodeficiencies: Epidemiology in the Maghreb

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Published Nov 14, 2018
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Vol. 96 No. 10 (2018): Issue Oct 2018

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Ahmed Aziz Bousfiha
Abderrrahmane Errami
Leila Jeddane
Fethi Mellouli
Shereen M Reda
Mehdi Adeli
Waleed Al-Herz
Raed Zyoud
Nahla Erwa
Yousif Suleiman
Rachida Boukari
Meriam Dakkoune
Abdelghani Yagoubi
Hamoud Al-Mousa
Rand Arnaout
Suleiman Alhamadi
Mohamed Bejaoui
Mohamed Ridha Barbouche
Bander AlSaoud
Hasan Al-Dhekri

Abstract

Introduction: Primary Immunodeficiency (PIDs) is a set of 330 rare hereditary diseases that increase susceptibility to infections, allergies, autoimmunity, and neoplasia. North American registries give higher prevalence than Maghreb ones, whereas consanguinity is high. The purpose of this study is to compare prevalence and coverage rate of Maghreb PID registries with estimates based on USA.
Methods: We searched the prevalence of PIDs in the Maghreb registers. Next, we estimated the expected values based on recent publications. Finally, we calculated the coverage rate of the Maghreb registries compared to the new estimates and we evaluated the impact of consanguinity.
Results: The total number is N1 = 2456 patients. The current Maghreb PID Prevalence is 2.56 / 100,000 inhabitants (population of 94,804,694 Million in 2017). Tunisia leads with a prevalence of 8.70 followed by Morocco 2.09, Libya 1.65 and Algeria 1.46/100.000 habitants. We did not find values for Mauritania. If we extrapolate the prevalence of the USA to the Maghreb population, the number of patients in the Maghreb would be N2 = 27,588 and the coverage rate (N1 / N2) would be 8.90%. This low coverage rate is however better than the World average (1.21%), that of Latin America 1.19% and Africa 0.36%. The Maghreb prevalence is close to that of the Arab world 2.04 / 100,000 (population of 391,449,544 in 2017). Using the incidence found in the USA, the number of patients would be 9765 new patients per year in the Maghreb and 40,319 in Arab countries.
Conclusion: PID Maghreb patients number is very low compared to global estimates, whereas consanguinity is very high. Special attention should be given to PIDs by governments and research teams in this region.

Keywords:

Immunologic Deficiency Syndromes - Genetics - Epidemiology - Africa, Northern.

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