Target therapy for metastatic breast cancer

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Published Oct 22, 2018
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Vol. 96 No. 8 (2018): Issue Aug 2018

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Haifa Rachdi
Amina Mokrani
Rim Batti
Mouna Ayadi
Nesrine Chraiet
Amel Mezlini

Abstract

Breast cancer is the first cancer in women worldwide. Since the previous estimates of WHO in 2008, incidence is increasing and it is estimated that 30% of women will develop immediately a metastatic form. However, advances in molecular biology and the discovery of new therapies have extended significantly the survival of patients and improved the quality of life of patients with metastatic breast cancer. The study of gene expression and protein profile has resulted in a finer classification of breast cancer and adapt the treatment of patients according to their molecular profiles. The purpose of our work is to describe the different targeted therapies used in the MBC and their action’s mechanism   referring to various therapeutic trials described in the literature.

Keywords:

targeted therapy; metastatic breast cancer; Her2neu; Antiangiogenic

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