Prognostic value of Ki67: comparison of the proliferation index between meningiomas with and without infiltration of glial tissue
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Abstract
Background: Although generally considered benign, meningiomas can cause significant morbidity and mortality. Histologic grade is the most useful morphologic predictor of recurrence.
Objectives: To compare Ki67 labeling index between meningioma grade I and meningioma grade II with brain invasion.
Methods: We analyzed 20 primary meningioma, 10 of which were grade I and 10 of which were grade II. Ki67 proliferative indices were determined in all cases.
Results: The patient population consisted of 9 males and 11 females with mean age of 60 years. For meningioma grade I, the Ki67 labeling index varied between 1 and 15% with an average of 3.1%. A diagnosis of gradeII meningiomas was made solely on the basis of brain invasion. The immunohistochemical study noted that the Ki67 index varied between 1 and 20% with an average of 6,8%.
Conclusion: The Ki67 labeling index shows a significant increase from grade I to grade II. It may provide useful prognostic information.
Keywords:
meningioma; immunohistochemistry; Ki67; prognosis##plugins.themes.academic_pro.article.details##
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