Attempted suicide by Flécainide overdose: A case report.

##plugins.themes.academic_pro.article.main##

Mouna Ben Kilani
Soufia Naccache
Rami Tlili
Dorra Mbarek
Salma Longo
Youssef Ben Ameur
Mohamed Rachid Boujnah

Abstract


Abstract:
Class Icantiarrythmic overdose is associated with a relatively high mortality. We presenta case report regarding a suicidal intoxication of an 18-year old female with a medical history of Wolff-Parkinson-White syndrome. The preliminary examination highlighted a profound cardiovascular collapse. The electrocardiogram showed a PR interval extended to 360 ms. The QRS complexes were enlarged to 360 ms with a right bundle brunch block appearance associated with left posterior hemibloc. There were repolarization abnormalities such as elevation of the J-point, convex ST segment and biphasic T wave in the right precordial leads (“Brugada-Like ECG pattern”). Sodium bicarbonate was administered. A rapid decrease in the duration of the QRS complexes was noted as well as a slowing of the heart rate. The electrocardiogram aspect on the 4th day showed the reappearance of the ventricular pre-excitation. The severity and lethal potential of Flecainide poisoning are linked to the cardiotoxic effects of these molecules. The prognosis remains poor despite progress in intensive care procedures.
 

Keywords:

Flecainide; Intoxication; Electrocardiogram; Sodium bicarbonate.

##plugins.themes.academic_pro.article.details##

References

  1. KöppelC,Oberdisse U,Heinemeyer G.Clinical course and outcome in class IC antiarrhythmic overdose. J Toxicol Clin Toxicol.1990;28(4):433-44.
  2. Roden DM,WoosleyRL. Drug therapy Flecainide.NEnglJMed. 1986;315(1): 36-41.
  3. Jaeger A, Sauder P. Les intoxications par les antiarythmiques de la classe I. In: Danel V, Barriot P, dir.Les intoxications aiguës. Paris: Arnette; 1993. p. 359-73.
  4. Hazouard E, Legras A, Dequin P, Perrotin D. Intoxications graves après ingestion modérée de flécaïnide deux observations. RéanUrg. 1998;7(5):599-602.
  5. Di Grande A, Giuffrida C, Narbone G, LeMoli C, Nigro F, DiMauro A, et al. Management of sodium-channel blocker poisoning: the role of hypertonic sodium salts. Eur Rev Med Pharmacol Sci. 2010;14(1):25-30.
  6. Soni S, Gandhi S. Flecainide overdose causing a Brugada-type pattern on electrocardiogram in a previously well patient. Am J Emerg Med. 2009;27(3):375.
  7. Tessitore E,Ramlawi M,Tobler O,Sunthorn H. Brugada Pattern Caused by a Flecainide Overdose.J Emerg Med.2016.DOI: 10.1016/j.jemermed.2016.10.045.
  8. Vu N, Hill T, Summers M, Vranian M, Faulx M. Management of life-threatening flecainide overdose: A case report and review of the literature. HeartRhythm Case Rep. 2016;2:228-231.
  9. Lloyd T,ZimmermanJ,Griffin GD.Irreversiblethird-degreeheartblockand pacemakerimplantinacaseof flecainide toxicity.AmJEmergMed.2013;31(9): 1418.e1-1418.e2.
  10. Brumfield E,BernardKR,KabrhelC.Life-threatening flecainide overdose treated withintralipidandextracorporealmembraneoxygenation.AmJEmerg Med. 2015;33(12):1840.e3-1840.e5