Child mortality infected with HIV1 followed in 40 pediatric care sites in Togo

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Ounoo Elom TAKASSI
Edem DJADOU
Piréwa ADI
Koffi Mawuse Guedenon
Mawouto FIAWOO

Abstract

Introduction: The infection in pediatric HIV is the reason a lot of problems in Africa The objective of our study were to identify factors associated with mortality during follow-up of children receiving antiretroviral therapy in Togo.

Methods: It was a cross-sectional study of 870 children aged files from 7 weeks to 15 years infected with HIV on antiretroviral treatment, covering the period 1 January 2001 to 31 December 2010 taking in 40 sites medical management in Togo. Data processing was done with the software Epi-Info 6.04d and duplicates were treated by the Software ESOPE.

Results: All patients were infected with HIV-1. In total forty six (46) deaths is 5.29% of the overall cohort were reported in our series. The lethality of the overall cohort followed for 60 months was 5.29%. The survival rate of the overall effective monitoring in our study was 89.2%. Fifty-eight percent (58%) of deaths had affected children in a state of severe malnutrition and forty two percent (42%) in a state of moderate malnutrition. Sixty two percent (62%) of children under HAART treatment died benefited monitoring a psychologist.

Conclusion: The diagnostic inadequacies of pediatric HIV strike the prognosis of infected children. Efforts still needs to be done to improve the load take pediatric HIV in Togo.

Keywords:

Mortality, children, HIV, Togo

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References

  1. ONUSIDA. Rapport sur l'épidémie mondiale du SIDA. Genève : ONUSIDA ; 2013 : 56 pages. Disponible sur : URL : http://www.unaids.org.
  2. Programme National de Lutte contre le SIDA et les Infections Sexuellement Transmissibles (PNLS-Togo). Rapport PNLS 2011. Lomé : Ministère de la Santé ; 2011 : 94 pages
  3. Tette EMA, Neizer M, Nyarko MY, et al. Changing Patterns of Disease and Mortality at the Children's Hospital, Accra: Are Infections Rising? PLoS ONE. 2016; 11(4): e0150387. doi:10.1371/journal.pone.0150387.
  4. Koueta F, Ouedraogo S.O, Boly C, et al. Morbidité et mortalité de l'infection à virus de l'immunodéficience humaine chez l'enfant en milieu hospitalier à Ouagadougou (Burkina Faso). Médecined'Afrique Noire.2016 ; vol. 63, N°4.
  5. Ekouevi DK, Azondekon A, Dicko F, et al. 12-month mortality and loss-to-program in antiretroviral-treated children: The DEA pediatric West African Database to evaluate AIDS (pWADA), 2000-2008. BMC Public Health 2011; 11:519-29.
  6. Janneke HVD, Sutcliffe CG, Munsanje B, et al. HIV-Infected Children in Rural Zambia Achieve Good Immunologic and Virologic Outcomes Two Years after Initiating Antiretroviral Therapy. PLoS ONE 2011; 6(4): e19006.
  7. Janssen N, Ndirangu J, Newell M-L, et al. Successful paediatric HIV treatment in rural primary care in Africa.Arch Dis Child2010; 95:414-21.
  8. Anaky M-F, Duvignac J, Wemin L, et al. Scaling up antiretroviral therapy for HIV-infected children inCôte d'Ivoire: determinants of survival and loss to programme. Bull World Health Organ 2010;88:490-499.
  9. Wamalwa DC, Obimbo EM, Farquhar C, et al.Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: a prospective cohort.BMC Pediatrics2010;10:33-41
  10. Brady MT, Oleske JM, Williams PL, et al. Declines in Mortality Rates and Changes in Causes of Death in HIV-1-Infected Children during the HAART Era. J Acquir Immune DeficSyndr. 2010; 53(1): 86-94.
  11. Edmonds A, Yotebieng M, Lusiama J, et al. The Effect of Highly Active Antiretroviral Therapy on the Survival of HIV-Infected Children in a Resource-Deprived Setting: A Cohort Study. PLoS Med. 2011;8(6): e1001044.
  12. Davies M-A, Egger M, Keiser O, et al. Paediatric antiretroviral treatment programmes in sub-Saharan Africa: a review of published clinical studies. Afr J AIDS Res. 2009; 8(3): 329-38.