Intraosseous hibernoma: a case report and review of the literature

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Published May 19, 2017
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Vol. 94 No. 10 (2016): Issue Oct 2016

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Manel Yahia
Issam M'sakni
Fethi Bougrine
Ammar Bouziani
Besma Laabidi

Abstract

Intraosseous hibernoma is a rare benign bone tumor, with only 4 cases reported in English literature.
Case report: In this report, we describe a 42-year-old man with  no past medical history and right chest pain. Imaging studies showed an osteolytic lesion with fat attenuation lesion in the right fourth rib. The lesion was completely resected and microscopic study showed mildly thickened bone trabeculae and multivacuolated brown fat cells replacing the normal white fat and hematopoietic elements. The diagnostic of intraosseous hibernoma was made.
Conclusion: Although it is rare, hibernoma should be included in the differential diagnosis of lipomatous  tumors.

Keywords:

Hibernoma, chest, tumors

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References

  1. Merkel H. On a pseudolipoma of the breast. Beitr Pathol Anat 1906;39:152-7.
  2. Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 2001;25(6): 809-14.
  3. Enerbäck S. The origins of brown adipose tissue. N Engl J Med 2009;360(19):2021-3.
  4. Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell 2007;131(2):242-56.
  5. Nedergaard J, Bengtsson T, Cannon B.Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007;293(2):E444-52.
  6. Celi FS. Brown adipose tissue—when it pays to be inefficient. N Engl J Med 2009;360:1553.
  7. Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 2001;25:809-14.
  8. Baskurt E, Padgett DM, Matsumoto JA. Multiple hibernomas in a 1-month-old female infant. Am J Neuroradiol 2004;25:1443-5.
  9. Lele SM, Chundru S, Chaljub G, Adegboyega P, Haque AK. Hibernoma: a report of 2 unusual cases with a review of the literature. Arch Pathol Lab Med 2002;126:975-8.
  10. Ong SY, Maziak DE, Shamji FM, Matzinger FR, Perkins DG. Intrathoracic hibernoma. Can J Surg 2002;45:145-6.
  11. Murphey MD, Carrol JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. Benign musculoskeletal lipomatous lesions. Radiographics 2004;24:1433-66.
  12. Gaskin CM, Helms CA. Lipomas, lipoma variants, and welldifferentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. AJR Am J Roentgenol 2004;182:733-9.
  13. Smith CS, Teruya-Feldstein J, Caravelli JF, Yeung HW. Falsepositive findings on 18F-FDG PET/CT: differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values. AJR Am J Roentgenol 2008; 190:1091e6.
  14. M. Hertoghs, P. Van Schil, Roger Rutsaert et al. Intrathoracic hibernoma: Report of two cases. Lung Cancer 64 (2009) 367-370
  15. Pedro Segui-Azpilcueta, Simona Espejo-Perez , Carlos Perez-Seoane et al. Thoracic hibernoma located in costodiaphragmatic recess. European Journal of Radiology Extra 60 (2006) 101-104
  16. Christopher D.M. Fletcher, K. Krishnan Unni, Fredrik Mertens. World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of Soft Tissue and Bone. IARCPress Lyon 2002, 33-34.
  17. Kumar R, Deaver MT, Czerniak BA, Madewell JE. Intraosseous hibernoma. Skeletal Radiol 2011;40:641-5.
  18. Reyes AR, Wilson JD, Desai HS. Intraosseous hibernoma of the femur: an unusual case with a review of the literature (poster #20). Coll Am Pathologists 2008;132:3.
  19. Thorns C, Schardt C, Katenkamp D, Kahler C, Merz H, Feller AC. Hibernoma-like brown fat in the bone marrow: report of a unique case. Virchows Arch 2008; 452(3):343-5.