Profile of bone malignancy among rheumatology inpatients in Lomé (Togo)

##plugins.themes.academic_pro.article.sidebar##

Published Jan 23, 2017
Download
pdf
Vol. 94 No. 8 (2016): Issue Aug 2016

##plugins.themes.academic_pro.article.main##

Kodjo Kakpovi
Owonayo Oniankitan
Messanvi Kpoti
Prénam Houzou
Viwalé ES Koffi-Tessio
Komi C Tagbor
Eyram Fianyo
Moustafa Mijiyawa

Abstract

ABSTRACT
Background: The incidence of bone malignancy in adulthood seems poorly known in Black Africa.
Aim: To determine the epidemiological, clinical, and paraclinical profile of bone malignancy in patients admitted to the Rheumatology Department in Lomé (Togo).
Methods: A retrospective study was conducted over 19 years on records of hospital patients admitted for bone malignancy.
Results: One hundred sixty-six of 2018 (8.2%) patients (98 men and 68 women) admitted suffered from bone malignancy. The mean age at admission of those 166 patients was 55 years with extremes of 14 and 98 years. The most affected age group was between 46 and 55 years (40 cases, 24.1%). The mean disease duration was 17 months. These tumors were primitive in 43 cases (26%) and secondary in 123 cases (74%). Metastases were prostate (44 cases, 35.7%), breast (12 cases, 9.7%) bronchi (7 cases, 5.7%), uterus cervix (5.7%), and liver (2 cases, 1.6%). Myeloma (34 cases; 79.0%) and osteosarcoma (9 cases; 20.9%) were the main primary malignant bone tumors. However 41 cases (33.3%) of tumors malignant bone could not be labeled. The spine was the main seat of those tumors.
Conclusion: This study demonstrates the substantial part occupy malignant bone tumors in the musculoskeletal diseases within the Sub-Saharan population in general and in Togo in particular.

Keywords:

Cancer; Bone tumors; Africa

##plugins.themes.academic_pro.article.details##

References

  1. Jemal A, Siegel R, Tiwari C et al. Cancer statistics 2004. CA Cancer J Clin 2004;54:8.
  2. Cancer Statistics for the UK. http://info.cancerresearchuk.org/cancerstats. Consulté le
  3. Virk MS, Lieberman J R. Tumor Metastasis to Bone Arthritis Res Ther 2007;9 Suppl 1:S5.
  4. Gremaud M, Delouche D, Monnerat C. Traitement des métastases osseuses par les biphosphonates. Revue médicale Suisse 2006;75:1-5.
  5. Bahebeck J, Atangana R, Eyenga V, Pisoh A, Sandoz Z, Hoffmeyer P. Bones tumors in Cameroon: incidence, demography and histopathology. Int Orthop 2003;27:315-7
  6. Sarma N.H, Al-fituri O, Visweswara RN, Saeed SO. Primary bone tumor in eastern Libya, a 10 year study. Cent Afr J Med 1994;40:418-51.
  7. Abdulkareem FB, Evesan SU, Akinde OR, Ezembakwe ME, Nnodu E. Pathological studies of bone tumors at the national orthopaedic hospital. West Afr J Med 2007;26:306-11.
  8. Daboiko JC, Eti E, Yapi I, Ouali B, Ouattara B, N'zué K. Les affections rhumatologiques inflammatoires ayant motivé une hospitalisation au centre hospitalo-universitaire de Cocody (Abidjan) entre mars 1998 et mars 2000. Rev. Rhum (Ed Fr.) 2004;74:1215-20.
  9. Omololu AB, Ogunbivi JO, Ogunlade SO, Alonge TO, Adebisi A, Akang EE. Primary malignant bone tumors in a tropical African University teaching hospital. West Afr J Med 2002;21:291-3.
  10. Baena-Ocampo C, Atangana R, Eyenga V, Pisoh A, Sandoz Z, Hoffmeyer P. Epidemiology of bones tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution. Ann diagn pathol. 2009;13:16-21.
  11. Settakorn J, Lekawanvijit S, Arpornchayanon O et al. Spectrum of bones tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1001 cases. J Med Assoc Thai 2006;89:780-7.
  12. Weber K , Damron TA, Frassica FJ, Sim FH. Malignant bones tumors. Instr. Course Lect 2008;57:673-88.
  13. Yeole BB, Jussawalla DJ. Descriptive epidemiology of bone cancer in greater Bombay. Indian J Cancer 1998;35:101-6.
  14. Oniankitan O, Houzou P, Kakpovi K et al. Profil des affections rhumatismales observées à Lomé. Guinée Méd;2009;66:46-53.
  15. Kouakoué N. Métastases osseuses en milieu hospitalier Ivoirien. Rhumatologie 1994;46:243-5.
  16. Belhaj R, Boussen H, Ghanem A, Essafer S. Bioclinical correlations in bony metastases. Results of a prospective study. 60 cases. Tunis Med 2002;80:691-5.
  17. Vandecandelaere M, Flipo R-M, Cortet B, Catanzariti L, Dusquenoy B, Delcambre B. Métastases osseuses révélatrices: étude comparative à 30 ans d'intervalle. Rev Rhum 2004;71:390-6.
  18. Hindié E, Zanotti-Fregonara P, Keller I et al. Bone metastases of differentiated thyroid cancer: impact of early 131 I-based detection on outcome. Endocr Relat Cancer 2007;14:799-807.