Prognostic factors predicting overall survival in Moroccan patients with myelodysplastic syndrome.

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Published Jan 23, 2017
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Vol. 94 No. 8 (2016): Issue Aug 2016

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Selim Jennane
Sanae Amelal
Mahtat El Mehdi
Samir Ahid
Nezha Messaoudi
Kamal Doghmi
Mohammed Mikdame

Abstract

Abstract :
Background: Prognostic scores are an indispensable tool in the management of myelodysplastic syndromes.
Aim: Identify prognostic factors influencing overall survival of patients with myelodysplastic syndromes.
Methods: We included all patients with myelodysplastic syndromes treated in the clinical hematology department of the military hospital of Rabat (Morocco).
Results: Seventy-four patients were included. The sex ratio [M / F] was 1.8. The median age was 65.5 years. The median follow-up was 45 months. The karyotype prognostic was good in 74%. In univariate analysis, prognostic factors influencing overall survival are: Age (p = 0.024), karyotype (p = 0.033), rate of bone marrow blasts (p = 0.002), transfusion dependence (p = 0.002), number of cytopenias (p = 0.001), hemoglobin (p = 0.009) and neutrophil count (p = 0.003). In multivariate analysis the only prognostic factor that influenced overall survival was the karyotype (p = 0.036). Transfusion dependence (p = 0.072) and the rate of marrow blasts (p = 0.107) was close to significance. The WHO Prognostic Scoring System (WPSS), the International Prognostic Scoring System (IPSS) and the Revised International Prognostic Scoring System (RIPSS) influence overall survival with a statistical significance (p <0.001).
Conclusion: Our study confirms the prognostic value of the karyotype and validated the WPSS, the IPSS and the RIPSS scores as significant predictors of overall survival in Moroccan patients with myelodysplastic syndromes.

Keywords:

Myelodysplastic syndrome; overall survival; karyotype; prognostic.

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