Role of metalloproteinases MMP-2 in asthma

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Published Nov 29, 2016
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Vol. 94 No. 6 (2016): Issue Jun 2016

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Sonia Toujani
Nadia Mehiri
Kamel Hamzaoui
Hela Hadded
Nozha Ben Salah
Meriem Mjid
Yacine Ouahchi
Bechir Louzir
Jalloul Daghfous
Jouda Cherif
Majed Beji

Abstract

Abstract:
Background: Many metalloproteinases (MMPs) play a role in the pathogenesis and modulation of the severity of asthma. MMP-9 is the predominant in asthma but other MMPs are involved such as the MMP-2.
Aim: To determine the role of single nucleotide polymorphism of the gene MMP2 in susceptibility to asthma and its severity.
Methods: Study case-control with prospectively enrolled patients with asthma and healthy subjects. We determined within two groups genotypes corresponding to the MMP2 polymorphism in -735C / T position, using a polymerase chain amplification technique associated with a polymorphism in the length of restriction fragments.
Results: We included 150 patients with asthma and 150 healthy controls. Comparison of allele and genotype frequencies of the studied polymorphisms between patients and controls showed that there was no association between the SNP-735C / T and susceptibility to asthma and its severity.
Conclusion: The role of MMP 2 in asthma remains unclear and no study has been conducted till date, to determine the role of MMP-2 -735C/T gene polymorphism in asthma. This study does not disprove such association. Further studies are needed to clarify the exact role the pathogenesis of asthma.

Keywords:

Asthma- metalloproteinases- inflammation

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