Performance of ultrasound fetal weight estimation in twins.

##plugins.themes.academic_pro.article.main##

Kaouther Dimassi
Abir Karoui
Amel Triki
Mohamed Faouzi Gara

Abstract

ABSTRACT :
Background: Ultrasonography is an essential tool in the management of twin pregnancies. Fetal weight estimation is useful to anticipate neonatal care in case of weight restriction or growth discordance.
Aims: To assess the accuracy of estimated fetal weight (EFW) in twins and to assess the accuracy of sonographic examination to predict birth weight discordance (BWD) and small birth weight (SBW).   
Methods : This was  a longitudinal prospective study over a period of one year. We have included 50 twin pregnancies with a first trimester ultrasound calculated term and specified chorionicity. An ultrasound EFW was scheduled for all patients within an interval of 4 days before delivery. We calculated the differences between EFW and BW in terms of absolute difference and percentage error. We studied the correlation and the agreement between EFW and BW. Finally we calculated the sensitivity, the specificity, PPV and NPV of ultrasound in the diagnosis of BWD and SBW.
Results : Absolute differences between BWF and BW were similar for the two twins. The relative difference was 7.7% [0-32] for T1 and 8.2% [0-27] for T2. The margin of error was greater than 10% in 38% of the cases for T1 and in 34% of cases for T2.
Furthermore, correlation coefficients R1 and R2 for T1 and T2 were close to 1; R 1 =0.87 and  R 2 = 0.89. Linear regression analysis allowed us to calculate the birth weight based on the estimated weight and this according to the following equations:
For the first twin BW T1 = 0.846 * EFW 415,57+ T1
For the second twin BW T2 = 65.68 + 0.963 * EFW T2 in 34% of cases for T2.
Chorionicity, presentation and gestational age did not affect the estimations. Ultrasonography in the diagnosis of SBW had a sensitivity of 90.32%, a specificity of 76.82%, a (PPV) of 80% and a (VPN) of 87%. The performance of ultrasound in the diagnosis of BWD varied according to the adopted threshold.
Conclusion : Ultrasound is an effective examination to estimate twins weight. Regarding prenatal diagnosis of birth weight discordance, the relevance of this examination increases with the adopted threshold.

Keywords:

Ultrasound- twin pregnancy- fetal weight estimation - birth weight discordance .

##plugins.themes.academic_pro.article.details##

References

  1. Branum AM, Schoendorf KC. The effect of birth weight discordance on twin neonatal mortality. Obstet Gynecol 2003; 101:570-4.
  2. Danon D, Melamed N, Bardin R, Meizner I. Accuracy of ultrasonographic fetal weight estimation in twin pregnancies. Obstet Gynecol 2008; 112:759-64.
  3. Mottet N, Guillaume M, Martin A, Ramanah R, Riethmuller D. Birth weight discordance in dichorionic twins: Diagnosis, obstetrical and neonatal prognosis. Gynecol Obstet Fertil 2014; 25:572-8.
  4. Ivars J, Houfflin-Debarge V, Vaast P, Deruelle P. Accuracy of ultrasonography fetal weight estimation in twin pregnancies. Gynecol Obstet Fertil 2010; 38:740-6.
  5. Ducarme G, Seguro E, Chesnoy V, Davitian C, Luton D. Estimation of fetal weight by external abdominal measurements and fundal height measurement near term for the detection of intra-uterine growth retardation. Gynecol Obstet Fertil 2012; 40:642-6.
  6. Hadlock FP, Harrist RB, Sharman RS, Deter RL, Park SK. Estimation of fetal weight with the use of head, body, and femur measurements-a prospective study. Am J Obstet Gynecol 1985; 151:333-7.
  7. Bland JM, Altman DG. Statistical methods for assessing agree-ment between two methods of clinical measurement. Lancet 1986;1:307—10.
  8. Ong S , Smith AP, Fitzmaurice A, Campbell D. Estimation of fetal weight in twins: a new mathematical model. Br J Obstet Gynecol 1999; 106:924-8.
  9. Diaz-Garcia , Bernard JP , Ville Y, Salomon L J. Validity of sonographic prediction of fetal weight and weight discordance in twin pregnancies. Prenat Diagn 2010; 30:361-367.
  10. Vergani P, Locatelli A, Ratti M et al. Preterm twins: what threshold of birth weight discordance heralds major adverse neonatal outcome? Am J Obstet Gynecol 2004; 191:1441-5.
  11. Gernt PR, Mauldin JG, Newman RB, Durkalski VL. Sonographic prediction of twin birth weight discordance. Obstet Gynecol 2001; 97:53-6.
  12. Stein W, Misselwitz B, Schmidt S. Twin-to-twin delivery time interval: influencing factors and effect on short-term outcome of the second twin. Acta Obstet Gynecol Scand 2008; 87:346-53.
  13. Kontopoulos EV, Ananth CV, Smulian JC, Vintzileos AM. The influence of mode of delivery on twin neonatal mortality in the US: variance by birth weight discordance. Am J Obstet Gynecol 2005; 192:252-6.
  14. Amaru RC, Bush MC, Berkowitz RL, Lapinski RH, Gaddipati S. Is discordant growth in twin an independent risk factor for adverse neonatal outcome? Obstet Gynecol 2004; 103:71-6.
  15. Simpson LL. Ultrasound in twins: Dichorionic and monochorionic. Semin Perinatol 2013; 37:348-58.
  16. Erkkola R, Ala-Mello S, Piiroinen O, Kero P, Sillanpää M. Growth discordancy in twin pregnancies: a risk factor not detected by measurements of biparietal diameter. Obstet Gynecol 1985; 66:203-6.
  17. Klam SL, Rinfret D, Leduc L. Prediction of growth discordance in twins with the use of abdominal circumference ratios. Am J Obstet Gynecol 2005; 192:247-51.
  18. Storlazzi E, Vintzileos AM, Campbell WA, Nochimson DJ, Weinbaum PJ. Ultrasonic diagnosis of discordant fetal growth in twin gestations. Obstet Gynecol 1987; 69:363-7.
  19. Hill LM, Guzick D, Chenevey P, Boyles D, Nedzesky P. The sonographic assessment of twin growth discordancy. Obstet Gynecol 1994; 84:501-4.
  20. Caravello JW, Chauhan SP, Morrison JC, Magann EF, Martin JN Jr, Devoe LD. Sonographic examination does not predict twin growth discordance accurately. Obstet Gynecol 1997; 89:529-33.
  21. Grobman WA, Parilla BV. Positive predictive value of suspected growth aberration in twin gestations. Am J Obstet Gynecol 1999; 181:1139-41
  22. Houze de l'Aulnoit A, Closset E, Deruelle P. Accuracy of ultrasound estimated fetal weight performed by OB-Gyn residents at due date. Gynecol Obstet Fertil 2009; 37(4):367-71
  23. Field NT, Piper JM, Langer O. The effect of maternal obesity on the accuracy of fetal weight estimation. Obstet Gynecol 1995; 86:102-7.