Factors related to treatment compliance in bipolar disorder

##plugins.themes.academic_pro.article.sidebar##

Published Jul 20, 2016
Download
pdf
Vol. 94 No. 1 (2016): Issue Jan 2016

##plugins.themes.academic_pro.article.main##

Hichem Kassaoui
Saoussen Bouhlel
Jaafar Nakhli
Imen Ben Mahmoud
Selma Ben Nasr
Béchir Ben Hadj Ali

Abstract

Background: Medication non-adherence is a major problem in patients with bipolar disorder as it is associated to poor clinical outcomes with frequent relapses and consequently poor quality of life. The reasons that patients are non adherent with medication are not well understood by clinicians who often consider it as related to the illness itself.   
Aims: To assess sociodemographic, clinical and therapeutic factors related to medication compliance in bipolar disorder.
Methods: A cross-sectional study was conducted at the department of psychiatry of FarhatHached Hospital of Sousse. We included 50 outpatients with bipolar disorder type I or II according to the criteria of the DSM-IV TR. The sociodemographic, clinical and therapeutic data were collected and adherence was evaluated with the Medication Adherence Report Scale (MARS) of Thompson.
Results: The mean age of our patients was of 31.9 years. The most frequent diagnosis was the bipolar disorder type I (60 %). Most of the participants were single (n=30; 60%), unemployed and living with their families. Factors associated to medication non-adherence were: young age, addiction, complexity and adverse effects of medications, lack of information about the disease and utility of treatments, low income and type I of bipolar disorder.
Conclusion: Improving medication compliance strategies in bipolar patients must take into account psycho education of patients about their disease and simplification of prescriptions that must be also well tolerated mainly in young subjects, having addictive behaviors and low income.

Keywords:

Bipolardisorder, Patient compliance, Adherence

##plugins.themes.academic_pro.article.details##

References

  1. Rouillon F. Epidémiologie du trouble bipolaire. Ann MedPsychol 2009 ; 167: 793-5. organization. Am J Psychiatry, 2002; 153:999-1000.
  2. Emilie L, Rodrigo B, Elisa B. Determinants of adherence to treatment in bipolar disorder: A comprehensive review.J Affect Disord2013; 149 (2013) 247-252.
  3. Myers ED, Midence V. Adherence to treatment in medical conditions. Buffalo, NY, Hardwood, 1998 : 1-24.
  4. American Psychiatric Association, Manuel diagnostique et statistique des troubles mentaux DSM-IV-TR, Edition Masson, Paris 2003, 1065 pages.
  5. Thompson K, Kulkarni J, Sergejew AA. Reliability and validity of a new Medication Adherence RatingScale (MARS) for the psychoses. SchizophrRes 2000;42:241-7.
  6. Lemperière T. Les troubles bipolaires. Acanthe, Masson Ed., Paris, 1995.
  7. Sayin A, Kuruoglua AC, Guleçb MY. Relation of temperament and character properties with clinical presentation of bipolar disorder. Compr Psychiatry 2007; 48:446-51.
  8. Lee S, Lam K, Tsang A. A community survey of the twelve-month prevalence and correlates of bipolar spectrum disorder in Hong Kong, J Affect Disorders 2009; 21 54-69.
  9. Robinson DG, Woerner MG, Alvir JM, Bilder RM, Hinrichsen GA, Lieberman JA. Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder. Schizophr Res 2002 ;57(2-3):209-19.
  10. Fenton WS, Blyler CR, Heinssen RK. Determinants of medication compliance in schizophrenia: empirical and clinical findings.1997;23(4):637-51.
  11. Bordenave-Gabriel C, Giraud-Baro E, De Beauchamps I,Bougerol T, Calop J. Pourquoi les patients souffrant de troubles psychotiques ne sont-ils pas observants à leurs médicaments ? L'Encéphale2003 : 213-22
  12. Bowskill R, ClatworthyJ, Parham R, Rank T, Horne R.Patients' perceptions of information received about medication prescribed for bipolar disorder: Implications for informed choice. J Affect Disorders 2007; 100: 253-7
  13. Palazzolo J. Observance médicamenteuse et psychiatrie. Paris: Elsevier; 2004.
  14. Gatti ME, Jacobson KL, Gazmararian JA et al. Relationships between beliefs about medications and adherence. Am J Health Syst Pharm 2009; 66: 657- 64.
  15. George J, Munro K, McCaig DJ et al. Prescription medications: beliefs, experiences, behavior, andadherence of sheltered housing residents. Ann Pharmacother 2006; 40:2123-9.
  16. Ross S, Walker A, MacLeod MJ. Patient compliance in hypertension: role of illness perceptionsand treatment beliefs. J Hum Hypertens 2004; 18:607-13.
  17. HouR et al. Do treatment and illness beliefs influence adherence to medicationin patients with bipolar affective disorder? A preliminary cross-sectional study. Euro Psychiatry 2010; 25: 216-9.
  18. Baldessarini RJ, Perry R, Pike J. Factors associated with treatmentnonadherence among US bipolar disorder patients. Hum Psychopharmacol2008;23(2):95-105.
  19. Sajatovic M, Jenkins JH, Cassidy KA, Muzina DJ. Medication treatment perceptions, concerns and expectations among depressed individuals with type I bipolar disorder. J Affect Disord. 2009; 115: 360-6.
  20. Othman. S et al. Bipolar disorders in children and adolescents:a clinical study from 50 cases. Ann Med Psychol 2005; 163: 138-40.
  21. Rosa A, Marco M, Fachel J, Kapczonski F, Stein A, Barros H. Correlation between drug treatment knowledge and lithium treatment attitudes and knowledge by bipolar patients. Progress in Neuro-Pschopharmacology and Biological Psychiatry 2007; 31: 217-24.
  22. Banayan M. et al. Conscience du trouble chez les sujets bipolaires euthymiques: Etude transversale comparative réalisée sur 60 patients.Ann Med Psychol. 2007; 165 : 247-53.
  23. Sajatovic M, Valenstein M, Blow FC et al. Treatment adherence with antipsychotic medications in bipolar disorder. BipolarDisord. 2006; 8 : 232-41.
  24. Gatti M.E, Jacobson KL, Gazmararian JA et al. Relationships between beliefs about medications and adherence. Am J Health-Syst Pharm 2009; 66: 657- 64.
  25. Keller DL, Wright J, Pace HA. Impact of health literacy on health outcomes in ambulatory care patients: a systematic review. Ann Pharmacother 2008; 42(9):1272-81.
  26. Blackwell B.Treatment compliance and the therapeutic alliance.Amsterdam: Harwood Academic Publishers, 1997.
  27. Lage M.J, Hassan M.K.The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder: a retrospective study. Ann Gen Psychiatry 2009 ; 8: 7.
  28. Crowe M, Wilson L, Inder M. Patients' reports of the factors influencing medication adherence in bipolar disorder - An integrative review of the literature.Inter J Nurs Studies 2011; 48 : 894-903
  29. Duran J, Phun YT, Bailey M et al. Development and validation of the medication regimen complexity index.Ann Pharmacol 2004;38:1369-76.
  30. Bernardini J,Piraino B. Compliance in CAPD and CCPD patients as measured by supplyinventories during home visits. Am J Kidney Diseases 1998; 31(1):101-7.
  31. Chewning B, Boh L, Wiederholt J et al. Does the concordance concept serve patient medication management? Int J Pharma Practice 2001;9 :71-9.
  32. Paes A, Bakker A,Soe-Agnie CJ. Impact of dosage frequency on patient compliance. Diabetes Care 1997; 20 : 1512-7.
  33. Blackwell B. Treatment adherence. Br J Psychiatry 1976 ; 129 : 513-31.
  34. Karen S, Cohen I.J. The impact of medication regimen factors on adherence to chronic treatment: areview of literature. J Behav Med 2008; 31: 213-24.
  35. Kardas P. The DIACOM study (effect of Dosing frequency of oral Antidiabetic agents on theCompliance and biochemical control of type 2 diabetes). Diabetes, Obesity and Metabolism 2005; 7:722-8.