Evaluation of the anemic condition of type 2 diabetes cases of the city of lubumbashi.

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Published Jan 13, 2016
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Vol. 93 No. 11 (2015): Issue Nov 2015

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Kabamba Tshikongo Arsène
Kipenge Kyandabike Richie
Mwaba Mulubwa Jean-Jacques
Mbayo Kalubandika Glauber
Mujinga Kayembe Rachel
Lukumwena Kalala Zet
Longanga Otshudi Albert

Abstract

SUMMARY
Background: Many non- hormonal abnormalities can be observed in type 2 diabetes, including hematological disturbances and especially anemia.
Aim : Determine biological characteristics of anemia in type 2 diabetes.
Methods : This is a case-control study conducted from June to August 2014 in Lubumbashi (Democratic Republic of Congo) where assays of serum hemoglobin (Hb) , measuring the mean corpuscular volume (MCV ) and the calculation of the rate hematocrit ( Hct ) were done in 30 people with type 2 diabetes (group I ) and in 30 other considered healthy with a normal rate of glucose ( group II). The results obtained were compared in the two groups and the level of significance was set at p <0.05.
Results : Seventeen patients with diabetes (57 %) had anemia, the mean age of patients was 55 ± 8.1 years for men and 48 ± 4.1 years in women. Hypo hemoglobin was found in 53 % of cases in male diabetics , reduced MCV in 47 % of cases and a filtration rate decrease glomerular in 33 % of cases. In the group of female diabetic patients, 60% of cases showed a hypo hemoglobin , MCV and decreased in 33 % of cases and a filtration rate decrease glomerular in 20 % of cases. In contrast, in the control groups of both sexes, the parameters studied rates remained in the standard.
Conclusion : Anemia is often found in diabetic patients. Its etiology appears to be dominated by the presence of diabetic nephropathy, in which the kidneys are affected by hyperglycemia and erythropoietin is affected and not known to produce red blood cells. These anemias rarely require a blood transfusion and well conducted etiological treatment allows the correction of the anemia.

Keywords:

Anemia , Type 2 diabetes , Lubumbashi.

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References

  1. Irzaks GJ, Westendrop RGJ, Knook DL. The definition of anemia in older persons. JAMA 1999; 281:1714-7.
  2. Zindrou D, Taylor KM, Bagger JP. Preoperative heamoglobin concentration and mortality rate after coronary artery bypass surgery. Lancet J 2002; 359:1747-8.
  3. Nazir N, Siddiqui K, Al-Qasim S, et al. Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways. BMC Med Genet 2014; 15:103.
  4. Wang L, Di L, Noguchi CT. Erythropoietin a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci 2014; 10:921-39.
  5. Bedani PL, Verzola A, Bergami M, et al. Erythropoietin and cardiocirculatory condition in aged patients with chronic renal failure. Nephron 2001; 89:350-3.
  6. Dousdampanis P, Trigka K, Fourtounas C. Prevalence of anemia in patients with type II diabetes and mild to moderate chronic Kidney disease and the impact of anti-RAS medications. Saudi J Kidney Dis Transpl 2014; 25:552-7.
  7. Zheng CM, Ma WY, Wu CC, et al. Glycated albumin in diabetic patients with chronic kidney disease. Clin Chim Acta 2012; 413:1555-61.
  8. Kim W J, Park CY. Anhydroglucitol in diabetes mellitus. Endocrine 2013; 43:33-40.
  9. Eshbach JW, Adamson JW. Anemia of end-stage renal disease (ESRD).Kidney Int 1985; 28:1-5.
  10. Moreno F, Aracil FJ, Perez R, et al. Controlled study on the improvement of quality life in elderly hemodialysis patients after correcting end-stage renal disease-related anemia with erythropoietin. Am J Kidney Dis 1996; 27:548-56.
  11. Loannidis L. Diabetes treatment in patients with renal disease: Is the Landscape clear enough?world J Diabetes 2014; 5:651-8.
  12. Lim AKH. Diabetic nephropathy-complications and treatment. Int J Nephrol Renovasc Dis 2014; 7:361-81.
  13. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16:31-41.
  14. Astor BC., Muntner P., Levin A., et al. Association of kidney function with anaemia : The third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 2002; 162: 1401-1408.
  15. Nicola O'Connell. L'anémie : une complication silencieuse du diabète. Diabetes Voice 2003 ; 48: 22.
  16. Isabelle Eustache. Les femmes végétariennes : une population à risque d'anémie. British Medical Journal 2001 ; 322 : 958-959.
  17. Akram K, Pearlman B. Congestive heart failure-related anemia and role for erythropoietin. International Journal of cardiology 2007; 117:296-305.
  18. Westenbrink BD., Voors AA., Ruifrok WPT. Therapeutic potential of erythropoietin in cardiovascular disease: erythropoiesis and beyond. Curr Heart Fail Resp 2007; 4:127-33.