Characteristics of deep vein thrombosis in the elderly

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Published Mar 30, 2015
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Vol. 93 No. 1 (2015): Issue Jan 2015

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Kechaou Ines
Ben Hassine Lamia
Cherif Eya
Hassayoun Marie
Azzabi Samira
Boukhris Imène
Kaouech Zouleikha
Koôli Chekib
Khalfallah Narjess

Abstract

Purpose of the study: Deep vein thrombosis is a common condition in geriatric. The identification of risk factors for venous thrombosis in the elderly is important because it allows an appropriate prescription of preventive treatments. The purpose of this study is to identify the etiologic and therapeutic characteristics of deep vein thrombosis of the lower limbs in the elderly.

Patients and methods: A retrospective study of 155 patients with lower limb deep vein thrombosis confirmed by venous Doppler. These patients were divided into two groups: group 1 (patients aged 65 years or more) and group 2 (patients whose age was below 65 years). A comparison between these two groups was performed.

Results: The average age of patients in group 1 was 74.89 years (± 6.43). The sex ratio in this group was 0.68. The thrombosis was more frequently proximal in patients of group 1. Patients of group 1 had significantly more risk factors than those of group 2 (p <0.05). Among risk factors studied, only the cancers were significantly more frequent in group 1 (p = 0.002). The frequency of hemorrhagic events in both groups was comparable but bleeding was more common in patients of group 1 with cancer.

Conclusion: Our study confirms the multifactorial origin of deep vein thrombosis in the elderly and the incidence of malignant etiology. The results of this study also call for vigilance in the use of anticoagulants in the elderly especially in the presence of cancer because it is an additional risk factor for bleeding.

Keywords:

Deep vein thrombosis, Risk factors, Geriatrics, Cancer

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References

  1. Oger E for the EPI-GETBO Study Group. Incidence of venous thromboembolism: a community based study in Western France. Thromb Haemost. 2000; 83: 657-660.
  2. Geerts WH, Bergqvist D, Pineo GF et al. Prevention of venous thromboembolism : American College of Chest Physicians evidencebased clinical practice guidelines (8th ed.). Chest 2008; 133: 381S-453S.
  3. Le Jeune S, Pistorius M-A, Planchon B, Pottier P. Risque thromboembolique veineux, au cours des affections médicales aigues. Partie 1 : Modèles pathogéniques fondamentaux et cliniques, épidémiologie descriptive et analytique. Rev Méd Interne 2008; 29: 452-61.
  4. Jeandel C, Blain H. Maladie thromboembolique veineuse du sujet âgé. Le risque thromboembolique chez le sujet âgé. La Press Med 1998; 27: 1448-50
  5. Pignon T, Rafaramino F, Scalliet P. Cancer et sujets âgés. Prise en charge. Aspects décisionnels. Rev Méd Interne 2000; 21: 765-76
  6. Chew HK, Wun T, Harvey D, Zhou H, White RH. Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med 2006; 166: 458-64
  7. White RH, Chew HK, Zhou H et al. Incidence of venous thromboembolism in the year before the diagnosis of cancer in 528,693 adults. Arch Intern Med 2005; 165: 1782-7
  8. Alcalay A, Wun T, Khatri V et al. Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival. J Clin Oncol 2006; 24: 1112-8.
  9. Mandala M, Ferretti G, Cremonesi M, Cazzaniga M, Curigliano G, Barni S. Venous thromboembolism and cancer : new issues for an old topic. Crit Rev Oncol hematol 2003; 48: 65-80.
  10. Fennerty T. Screening for a cancer in venous thromboembolic disease. BMJ 2001; 323: 704-705.
  11. Rance A, Emmerich J, Guedj C, Fiessinger JN. Occult cancer in patients with bilateral deep-vein thrombosis. Lancet 1997; 350: 1448-9.
  12. Mahé I, Caulin C, Bergmann J F. L'âge, facteur de risque indépendant de thrombose veineuses. Données épidemiologiques. La Press Med 2005; 34: 878-86.
  13. Coon W. Epidemiology of venous thromboembolism. Ann Surg 1977; 186:149-64
  14. Jansen HF, Schachner J, Hubbard J, Hartman JT. The risk of deep venous thrombosis : computerized epidemiologic approach. Surgery 1987; 101: 205-12.
  15. Wester JP, De valk HW, Nieuwenhuis HK et al. Risk factor for bleeding during treatment of acute venous thromboembolism. Thromb Haemost 1996; 76: 682-8.
  16. Gitter MJ, Jaeger TM, Petterson TM, Gersh BJ, Phil D, Silverstein MD. Bleeding and thromboembolism during anticoagulant therapy: a population based study in Rochester, Minesota. Mayo Clin Proc 1995; 70: 682-8.
  17. Chaix L, Chaix AF, Latour F et al. La malade veineuse thromboembolique chez la personne âgée de 80 ans et plus. Stratégies diagnostiques et thérapeutiques. Ann Cardiol Angéiol 1994; 43 : 437-42
  18. Fronek A, Criqui MH, Denenberg J, Langer RD. Common femoral vein dimensions and hemodynamics including valsalva response as a function of sex, age and ethnicity in a population study. J Vasc Surg 2001; 33: 1050-6.