The value of multimodal imaging by single photon emission computed tomography associated to X ray computed tomography (SPECT-CT) in the management of differentiated thyroid carcinoma: about 156 cases.

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Published Nov 14, 2013
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Vol. 91 No. 10 (2013): Issue Oct 2013

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Aida Mhiri
Intidhar El Bez
Ihsen Slim
Imène Meddeb
Imène Yeddes
Mohamed Ghezaiel
Saïd Gritli
Mohamed Faouzi Ben Slimène

Abstract

Background: Single photon emission computed tomography combined with a low dose computed tomography (SPECT-CT), is a hybrid imaging integrating functional and anatomical data. The purpose of our study was to evaluate the contribution of the SPECTCT over traditional planar imaging of patients with differentiated thyroid carcinoma (DTC).
methods: Post therapy 131IWhole body scan followed by SPECTCT of the neck and thorax, were performed in 156 patients with DTC.
results: Among these 156 patients followed for a predominantly papillary, the use of fusion imaging SPECT-CT compared to conventional planar imaging allowed us to correct our therapeutic approach in 26.9 % (42/156 patients), according to the protocols of therapeutic management of our institute .
Conclusion: SPECT-CT is a multimodal imaging providing better identification and more accurate anatomic localization of the foci of radioiodine uptake with impact on therapeutic management.

Keywords:

Differentiated thyroid carcinoma, hybrid imaging , tomo scintigraphy, Iodine131.

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References

  1. Leenhardt L, Borson - Chazot F .Cancers thyroïdiens de souche folliculaire : Actualité sur la prise en charge en 2011. Méd Clin endocrinol & diab 2011 ; 50 :12-20.
  2. Paycha F. Impact de l'évolution technologique sur les progrès cliniques et dosimétriques: TEMP/TDM (SPECT/CT), TEP temps de vol, caméras CZT. Méd Nuc 2011 ; 35(7): 397-398.
  3. El Badaoui A, De Clermont H,Valli N et al. Impact diagnostique de la TEMP-TDM dans l'exploration des tumeurs endocrines. Imagerie fonctionnelle et métabolique 2008 ; 32: 66-75.
  4. Schillaci O, Filippi L, Danieli R, Simonetti G. Single-photon emission computed tomographiy/computed tomography in abdominal diseases. Semin Nucl Med 2007; 37:48-61.
  5. Horger M, Eschmann SM, Pfannenberg C et al. Evaluation of combined transmission and emission tomography for classification of squeletal lesions. Am J Roentgenol 2004; 183: 655-61.
  6. Schmidt D , Szikszai A, Linke R , Bautz W, Kuwert T. Impact of 131I SPECT/Spiral CT on Nodal Staging of Differentiated Thyroid Carcinoma at the First Radioablation. J Nucl Med 2009; 50:1 18-23.
  7. Aide N, Heutte N, Rame J.P et al., Clinical relevance of singlephoton emission computed tomography/computed tomography of the neck and thorax in post ablation (131)I scintigraphy for thyroid cancer.J Clin Endocrinol Metab 2009; 94: 2075-2084.
  8. Kohlfuerst S, Igerc I, Lobnig M et al. Post therapeutic (131)I SPECT-CT offers high diagnostic accuracy when the findings on conventional planar imaging are inconclusive and allows a tailored patient treatment regimen. Eur J Nucl Med Mol Imaging2009; 36: 886-893.
  9. Chen L, Luo Q, Shen Y et al., Incremental value of 131I SPECT/CT in the management of patients with differentiated thyroid carcinoma. J Nucl Med 2008; 49: 1952-1957.
  10. Bardet S, Ciappuccini R, Aide N, Barraux V, Rame J.P. Imagerie hybride (TEMP/TDM, TEP/TDM) et cancer différencié de la thyroïde. Méd Nuc 2010; 34: 457-463.
  11. Meddeb I, Mhiri A, Slim I et al. Apport de l'imagerie hybride TEMP-TDM dans le suivi d'un cancer différencié de la thyroïde. Méd Nuc 2011 ; 35: 587-591.
  12. Pérault C, Schvartz C, Wampach H, Liehn J.C, Delisle M.J. Thoracic and abdominal SPECT-CT image fusion without external markers in endocrine carcinomas. The Group of Thyroid Tumoral Pathology of Champagne-Ardenne. J Nucl Med. 1997; 38:1234-1242.
  13. Tharp K, Israel O, Hausmann Jet al. Impact of 131ISPECT/CT images obtained with an integrated system in the follow-up of patients with thyroid carcinoma. Eur J Nucl Med Mol Imaging 2004; 31:1435-42.
  14. Yamamoto Y, Nishiyama Y, Monden T et al. Clinical usefulness of fusion of 131I SPECT and CT images in patients with differentiated thyroid carcinoma. J Nucl Med 2003; 44: 1905-10.
  15. Schillaci O. Hybrid SPECT/CT: a new era of SPECT imaging? Eur J Nucl Med Mol Imaging 2005; 32:521-24.
  16. Schillaci O, Danieli R, Manni C, Simonetti G. Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation? Nucl Med Commun 2004; 25: 705-10.
  17. Keidar Z, Israel O, Krausz Y. SPECT/CT in tumor imaging: technical aspects and clinical applications. Semin Nucl Med 2003; 33:205-18.
  18. Krausz Y, Israel O. Single-photon emission computed tomography /computed tomography in endocrinology. Semin Nucl Med 2006; 36: 267-74.