Dermatofibrosarcoma protuberans: A study of 18 cases
##plugins.themes.academic_pro.article.main##
Abstract
Background: Dermatofibrosarcoma protuberans is the most common mesenchymatous skin tumor. It is often diagnosed late because of its slow development and the lack of symptoms.
Aim: To elucidate the epidemio-clinical characteristics of dermatofibrosarcoma in our study.
methods: We report a retrospective study of 18 cases of DFS between 1989 and 2009.
results: Mean age at diagnosis was 45.2 years. The average delay before consultation was 45.7 months. Three patients reported a history of trauma. The tumor was mainly located on the trunk or the back. The diagnosis of dermatofibrosarcoma protuberans was histologically confirmed in all cases. Immunohistochemical study was achieved in 6 cases and showed positive staining for CD34. The treatment consisted of surgical excision in all patients.
Conclusion: Dermatofibrosarcoma protuberans is a low-malignancy potential skin tumor. Treatment of choice is surgery. The main risk is tumor relapse.
Aim: To elucidate the epidemio-clinical characteristics of dermatofibrosarcoma in our study.
methods: We report a retrospective study of 18 cases of DFS between 1989 and 2009.
results: Mean age at diagnosis was 45.2 years. The average delay before consultation was 45.7 months. Three patients reported a history of trauma. The tumor was mainly located on the trunk or the back. The diagnosis of dermatofibrosarcoma protuberans was histologically confirmed in all cases. Immunohistochemical study was achieved in 6 cases and showed positive staining for CD34. The treatment consisted of surgical excision in all patients.
Conclusion: Dermatofibrosarcoma protuberans is a low-malignancy potential skin tumor. Treatment of choice is surgery. The main risk is tumor relapse.
Keywords:
Dermatofibrosarcoma, surgery##plugins.themes.academic_pro.article.details##
References
- Triki S., Fazaa B., Zermani R., et al. Le dermatofibrosarcome de Darier et Ferrand, étude de 28 cas chez l'adulte. Tunis. Med 2005; 83: 457.
- Declerk D., Claye C., Rotteleur G., et al. Dermatofibrosarcome de Darier Ferrand. Etude immunohistochimique de 38 cas à la recherche d'un marqueur spécifique. Ann. Pathol 1997;17:324.
- Vignon-Pennamen M.D., Verola O., Champeau F.: Sarcomes cutanés. « Encycl. Med. Chir. », Dermatologie, 98-650-A-10, 14p, Elsevier SAS, Paris.
- Kostrzewa E., Beylot-Barry M., Vergier B., et al. Dermatofibrosarcome atrophique multifocal à début pédiatrique. Ann. Dermatol. Venereol 2006; 133: 359.
- Verret JL, Leclech C.: Quel est votre diagnostic? Ann. Dermatol. Venereol 1991;118: 231.
- Schllhammer M., Guillet M.H., Sassolas B., et al. Dermatofibrosarcome de Darier-Ferrand de l'enfant. Arch. Pediatr 1995; 2:750.
- Kourda M., Krichen H., Kennou H., et al. Association d'un fibroblastome à cellules géantes et d'un dermatofibrosarcome de Darier Ferrand chez un adulte. Ann. Dermatol. Venereol 1998;125: 255.
- Joucdar S, Kismoune H, Boudjemia F, et al. Les dermatofibrosrcomes de Darier et Ferrand. Analyse rétrospective de 81 cas sur dix ans (1983-1994). Ann. Chir. Plast. Esthet 2001; 46:134.
- Taleb A., Fahoume K., Hommadi A., et al. Apport de l'imagerie dans le diagnostic du dermatofibrosarcome crânio-facial de Darier-Ferrrand à propos de deux observations. J. Neuroradiol 2001;28: 272.