Atypical presentations of internal mammary chain involvement in breast cancer

##plugins.themes.academic_pro.article.main##

Mongi Maalej
Walid Gargouri
Dalenda Hentati
Taha Messai
Lotfi Kochbati
Ali Chebbi
Amor Saadi
Karima Mrad
Khaled Ben Romdhane

Abstract

Bachground: Breast cancer is the first cancer in women. Lymphatic involvement in breast cancer is common, especially in our patients because of the frequency of locally advanced forms. This contrast with a weak rate of diagnosed internal mammary chain invasion.
Methods: We present observations of patients presenting atypical forms of internal mammary chain involvement.
Aim: To clarify the atypical presentations of internal mammary chain involvement in breast cancer.
Results: The invasion of internal mammary chain is often underestimated. Indeed, this site of lymphatic spread is not accessible to the clinical exam and its radiological exploration is not systematic. Otherwise, different clinical, pathological and radiological presentations have to attract our attention to a potential
internal mammary chain invasion.
Conclusion: Our misrecognition of this site of spread and its different presentations can partly explain the lack of diagnosis.

Keywords:

Internal mammary chain, breast cancer, atypical presentations.

##plugins.themes.academic_pro.article.details##

References

  1. Maalej M, Hentati D, Messai T et al. Breast cancer in Tunisia in 2004: a comparative clinical and epidemiological study. Bull. Cancer 2008, 95: E5-9
  2. Early Breast Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005, 366:2087-106
  3. Farrus B, Vidal-Sicart S, Velasco M et al. Incidence of internal mammary node metastases after sentinel lymph node technique in breast cancer and its implication in the radiotherapy plan. Int. J. Radiation Biol. Phys. 2004, 60: 715-21
  4. Estourgie SH, Tanis PJ, Nieweg OE et al. Should the hunt for internal mammary chain sentinel nodes begin? An evaluation of 150 breast cancer patients. Ann Surg Oncol 2003, 10: 935-41
  5. Johnson N, Soot L, Nelson J et al. Sentinel node biopsy and internal mammary lymphatic mapping in breast cancer. Am J Surg 2000, 179: 386-88.
  6. Olivier JB, Verhaeghe JL, Butarelli M et al. Anatomie fonctionnelle du drainage lymphatique du sein: apport de la technique du lymph node sentinelle. Ann Chir2006, 131: 608-15
  7. Paganelli G, Viale G, Veronesi U. Sentinel nodes scintigraphy of the internal mammary chain in breast cancer. Nuclear instruments and methods in physics research 2003, 497:110-3
  8. Marks LM, Bentel GC, Hardenbergh PH et al. A practical and easy method to locate first three internal mammary lymph node-bearing areas. Int. J Radiation biol. Phys. 2001, 50: 421-5
  9. Van der Ent FWC, Kengen RAM, Van der Pol HAG et al. Halsted revised: internal mammary sentinel lymph node biopsy in Brest cancer. Ann. Surg. 2001, 234:79-84
  10. Galimberti V, Veronesi P, Arnone P et al. Stage migration after biopsy of internal mammary chain lymph nodes in Breast cancer patients. Ann. Surg. Oncol. 2002, 9: 924-8
  11. Ben Mansur D, El Naqa I, Kong F et al. Localization of internal mammary lymph nodes by CT simulation: implication for breast radiation therapy planning. Radiother Oncol 2004, 73: 355-7
  12. Kirova YM, Servios V, Campana F et al. CT-scan based localization of the internal mammary chain and supra clavicular nodes for breast cancer radiation therapy planning. Radiother Oncol 2006, 79: 310-5
  13. Maalej M, Frikha H, Ben Salem S et al. Le cancer du sein en Tunisie: étude clinique et épidémiologique. Bull. Cancer 1999, 86: 302-6.
  14. Tanis PJ, Nieweg OE, Valdés Olmos RA et al. Impact of non-axillary sentinel node biopsy on staging and treatment of breast cancer patients. Br J Cancer 2002, 87:705-10.
  15. Sobin L.H et Wittekind CH. TNM classification of malignant tumours. International Union Against Cancer 2002, 6th edition
  16. Eubank WB, Mankoff DA, Takasugi J et al. 18Fluorodeoxyglucose positron emission tomography to detect mediastinal or internal mammary metastases in breast cancer. J Clin Oncol 2001, 19: 3516- 23
  17. Cranenbroek S, Maurice J.C, van der Sangen MJ et al. Diagnosis, treatment and prognosis of internal mammary lymph node recurrence in breast cancer patients. Breast Cancer Res Treat 2005 89:271-75