Immunogenetics of psoriasis: Update

##plugins.themes.academic_pro.article.sidebar##

Published Jul 5, 2012
Download
pdf
Vol. 90 No. 7 (2012): Issue Jul 2012

##plugins.themes.academic_pro.article.main##

Myriam Ammar
Inés Zaraa
Chiraz Bouchlaka-Souissi
Nejib Doss
Raouf Dhaoui
Amel Ben Osman
Mourad Mokni
Amel Ben Ammar El Gaaied

Abstract

Bachground: Psoriasis is a chronic inflammatory skin disease often benign, affecting 2-3% of the total world population. Psoriasis is a multifactorial disease.
Aim: To present recent advances in the immunologic mechanisms and susceptibility genes involved in the pathogenesis of psoriasis.
Methods: We presented a literature review of recent genetic and immunological basis of psoriasis to better understand the pathomecanisms of this disease and discuss the contribution of the Tunisian work in this area.
Results: Recent works focalized mainly in immunology and genetics. Current progresses in molecular biology have allowed to better characterize the immunogenetic abnormalities in psoriasis.
Conclusion: Psoriasis is a multifactorial disease model in which environmental factors (psychological, climate, traumatic, infectious, and viral) seem to be triggering factors when associated with a particular immunogenetics predisposition.

Keywords:

Psoriasis, immunology, genetics

##plugins.themes.academic_pro.article.details##

References

  1. Ammar M, Zaraa I, Ammar M, et al . Familial psoriasis: descriptive report of 9 families. Tunis Med. 2009; 87: 750-4.
  2. Arnold R, Seifert M, Asadullah K, Volk H. D. Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines. J Immunol 1999: 162; 7140-47.
  3. Bata-Csorgo Z, Hammerberg C, Voorhees JJ, Cooper KD. Intralesional T-lymphocyte activation as a mediator of psoriatic epidermal hyperplasia. J Invest Dermatol 1995: 105; 89S-94S.
  4. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007: 445; 866-73.
  5. Bos JD, De Rie MA. The pathogenesis of psoriasis: immunological facts and speculations. Immunol Today 1999: 20: 40-46.
  6. Krueger JG. The immunologic basis for the treatment of psoriasis with new biologic agents. J Am Acad Dermatol 2002; 46: 1-23.
  7. Gottlieb SL., Gilleaudeau P, Johnson R et al. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat Med 1995; 1: 442-47.
  8. Tyring S, Gottlieb A, Papp K, et al. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet 2006; 367: 29-35.
  9. Fierlbeck G, Rassner G, Muller C. Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations. Arch Dermatol 1990: 126: 351-55.
  10. Nestle FO., Turka, LA., Nickoloff BJ. Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. J Clin Invest 1994;94: 202-9.
  11. Bowcock, A. M., Krueger, J. G. Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 2005; 5: 699-711.
  12. Nickoloff, B. J. Cracking the cytokine code in psoriasis. Nat Med 2007; 13: 242-44.
  13. Prinz, JC. The role of T cells in psoriasis. J Eur Acad Dermatol Venereol 2003: 17: 257-70.
  14. Szabo SK., Hammerberg C., Yoshida Y, Bata-Csorgo Z., Cooper KD. Identification and quantitation of interferon-gamma producing T cells in psoriatic lesions: localization to both CD4+ and CD8+ subsets. J Invest Dermatol 1998; 111: 1072-78.
  15. Arnold R., Seifert M., Asadullah K, Volk HD. Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines. J Immunol 1999; 162: 7140-47.
  16. Austin LM., Coven TR., Bhardwaj N., Steinman R., Krueger JG. Intraepidermal lymphocytes in psoriatic lesions are activated GMP-17(TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysis. J Cutan Pathol 1998; 25: 79-88.
  17. Behrendt, C., Gollnick, H., Bonnekoh, B. Up-regulated perforin expression of CD8+ blood lymphocytes in generalized nonanaphylactic drug eruptions and exacerbated psoriasis. Eur J Dermatol 2000; 10: 365-69.
  18. Yawalkar, N., Schmid, S., Braathen, L. R., Pichler, W. J. Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis. Br J Dermatol 2001; 144: 1133-39.
  19. Favre, M., Majewski, S., Noszczyk, B., et al. Antibodies to human papillomavirus type 5 are generated in epidermal repair processes. J Invest Dermatol 2000; 114: 403-7.
  20. Perez-Lorenzo R., Zambrano-Zaragoza, JF., Saul A., Jimenez- Zamudio L., Reyes-Maldonado E., Garcia-Latorre E. Autoantibodies to autologous skin in guttate and plaque forms of psoriasis and cross-reaction of skin antigens with streptococcal antigens. Int J Dermatol 1998; 37: 524-31.
  21. Torres, B. A., Johnson, H. M. Modulation of disease by superantigens. Curr Opin Immunol 1998; 10: 465-70.
  22. Nielsen MB, Odum N., Gerwien J, et al. Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines. Tissue Antigens 1998; 52: 530-38.
  23. Horiuchi N, Aiba S., Ozawa H, et al,. Peripheral blood lymphocytes from psoriatic patients are hypo responsive to betastreptococcal superantigens. Br J Dermatol 1998; 138: 229-35.
  24. Teunissen MB., Koomen, CW, de Waal Malefyt R, Wierenga, E. A., Bos J. D. Interleukin-17 and interferon-gamma synergize in the enhancement of pro inflammatory cytokine production by human keratinocytes. J Invest Dermatol 1998; 111: 645-49.
  25. Samoud El Samoud El Kissi S, Cherif Ben Hmida F, Ben Osman Dahri A, Boubacker MS, Hechmi-Louzir M. Intralesional and anatomopathologic features of psoriatic erythroderma. Tunis Med 2007; 85: 573-5.
  26. Samoud-El Kissi S, Galai Y, Sghiri R, et al. BAFF is elevated in serum of patients with psoriasis: association with disease activity. Br J Dermatol 2008; 159: 765-8.
  27. Elder JT, Nair RP, Henseler T, et al. The genetics of psoriasis 2001: the odyssey continues. Arch Dermatol 2001. 137: 1447-54.
  28. Bowcock AM., Cookson WO. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet 2004:1:43-55.
  29. Zhou X., Krueger J. G., Kao M. C., et al. Novel mechanisms of Tcell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 2003; 13: 69-78.
  30. Mallon, E., Newson, R., Bunker, C. B. HLA-Cw6 and the genetic predisposition to psoriasis: a meta-analysis of published serologic studies. J Invest Dermatol 1999; 113: 693-95.
  31. Birnbaum RY, Zvulunov A., Hallel-Halevy D, et al. Seborrhealike dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. Nat Genet 2006; 38: 749-51.
  32. Zhang XJ., He, PP., Wang ZX., et al. Evidence for a major psoriasis susceptibility locus at 6p21(PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans. J Invest Dermatol 2002; 119: 1361-66.
  33. Zhang XJ., Huang W, Yang S, et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 2009; 41: 205-10.
  34. Zhou X., Krueger JG., Kao MC., et al. Novel mechanisms of Tcell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 2003; 13: 69-78.
  35. Allen, M., Ishida-Yamamoto, A., McGrath, J., et al. Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disorders. Lab Invest 2001; 81: 969-76.
  36. Capon, F., Semprini, S., Chimenti, S., et al. Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21. J Invest Dermatol 2001; 116: 728-30.
  37. Friberg, C., Bjorck, K., Nilsson, S., Inerot, A., Wahlstrom, J., Samuelsson, L. Analysis of chromosome 5q31-32 and psoriasis: confirmation of a susceptibility locus but no association with SNPs within SLC22A4 and SLC22A5. J Invest Dermatol 2006; 126: 998-1002.
  38. Liu, Y., Helms, C., Liao, W., et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008; 4: e1000041.
  39. Lee, Y. A., Ruschendorf, F., Windemuth, C., et al. Genomewide scan in german families reveals evidence for a novel psoriasissusceptibility locus on chromosome 19p13. Am J Hum Genet 2000; 67: 1020-24.
  40. Nair, R. P., Duffin, K. C., Helms, C, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009; 41: 199-204.
  41. Hwu WL., Yang, CF., Fann, CS., et al. Mapping of psoriasis to 17q terminus. J Med Genet 2005; 42: 152-58.
  42. Sagoo, G. S., Tazi-Ahnini, R., Barker, J. W., et al. Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population. J Invest Dermatol 2004; 122: 1401-405.
  43. Veal, C. D., Capon, F., Allen, M. H., et al. Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus. Am J Hum Genet 2002; 71: 554-64.
  44. Ammar, M., Bouchlaka-Souissi, C., Rebai, A., et al. Linkage analysis of three genetic loci for disease susceptibility in Tunisian Psoriatic families. J Dermatol Sci 2009; 54: 137-39.