Protein S, C and antithrombin deficiency: Association to myocardial infarction and thromboembolism in young

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Published Apr 23, 2012
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Vol. 90 No. 4 (2012): Issue Apr 2012

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Neila Ben Romdhane
Hela Baccouche
Sonia Ammar
Sonia Mahjoub
Sonia Chabrak

Abstract

Background: The pathogenesis of myocardial infarction (MI) in young involves new factors including constitutional or acquired thrombophilia.
Aim: To determine in patients ² 50 years, the association between coagulation factors deficiency, myocardial infarction and cardiovascular events during follow-up.
Methods: Protein C (PC), PS and antithrombin (AT) were screened in 50 patients admitted for acute MI and in a healthy control group. Univariate and multivariate analysis were performed using SPSS 11.5 version.
Results: PS and PC deficiency were associated to MI (respectively 24% vs 0%, p=0.001 and 14% vs 0%, p=0.016), independently for PC. No AT deficiency was detected in both groups. During followup, PS and C deficiency were predictive for venous thrombosis (p<0.05) and PS deficiency for pulmonary embolism.
Conclusion: Protein C and S deficiency may play an important role in MI in young and also in thromboembolic complications during follow-up. Nevertheless, therapeutic implications remain controversial.

Keywords:

Myocardial infarction - young - protein S - protein C - antithrombin

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