Use Of Catecholamine and shocks. Continuous Debate!

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Published Apr 21, 2012
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Vol. 90 No. 4 (2012): Issue Apr 2012

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Mabrouk Bahloul
Mohamed Samet
Anis Chaari
Najla Ben Aljia
Mohamed Nouri Ben Mbarek
Hedi Chelly
Hassen Dammak
Chokri Ben Hamida
Noureddine Rekik
Hatem Kallel
Mounir Bouaziz

Abstract

Background: Hypotension and shocks are frequently observed in patients requiring admission in ICU. However, the optimal adrenergic support in shock is controversial.
Aim: To perform a descriptive approach of the current use of catecholamine in a medico-surgical ICU in patients with schoks.
Methods: Our study is prospective over 3 month period. Were included all patients admitted in our ICU during the study period’s. We compared the populations with and without catecholamine, we analysed the catecholamine selected in various clinical settings and we studied the impact of the use of catecholamine on the patient outcomes.
Results: During the study’s period, 226 patients were hospitalized in our service and were the subject of this study. The median age (± SD) was of 47± 24 years. During their hospitalization in the ICU, 132 patients (58.4%) presented a shock. The cardiogenic shock and the hypovolemic shock were the most observed (37.8% and 35.6% respectively). Hundred thirty patients (57.5%) received catecholamines during their stay in ICU. Eighty four patients (64.6% of the patients having received catecholamines) had received dopamine. Sixty two patients (47.7% of the patients having received catecholamines) had received dobutamine, 63 patients (48.5%) had received epinephrine and 22 patients (16.9%) had received norepinephrine. The mean’s period of catecholamines use was 5 ± 4 days. Among drugs proposed in order to manage patients with cardiogenic shock, dobutamine was chosen as the first choice agent in 62% of the cases. Among drugs proposed in order to manage patients with septic shock, Dopamine was chosen as the first choice agent in 85.7 % of the cases. In our study the patients of the class C or D in the Knauss classification are significantly predisposed to receive catecholamines during their ICU stay (OR: 5.3 ; IC 95% : 1.7 – 5.7).Moreover, the needing of catecholamine use is strongly associated with high mortality (OR: 16,8; IC 95% : 16.4 – 49.2).
Conclusion: The choice of catecholamines is a matter of debate for critically ill patients. The use of catecholamines is a clinical marker of severity and provider of mortality.

Keywords:

Catecholamine, ICU, Septic Shock, Cardiogenic Shock, Outcome

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