Pathophysiology of complex regional pain syndrome (CRPS) type 1

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Published Apr 20, 2012
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Vol. 90 No. 4 (2012): Issue Apr 2012

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Dalila Mrabet
Chékib Khémiri
Inès Ben Mrad
Héla Mrabet
Hamza Essaddem
Mrabet Amel
Héla Sahli
Slaheddine Sellami

Abstract

Background: If the pathophysiology of complex regional pain syndrome (CRPS) type 1 remains controversial, most authors agree on a combination in varying proportions, a sensitization of peripheral nerves.
Aim: To describe the state of advances in the physiopathology of complex regional pain syndrome type 1.
Methods: Bibliographic research and literature review performed by referring to databases (Medline, Science Direct)
Results: The physiopathology of complex regional pain syndrometype 1 remains still poorly understood and controversial. Several arguments demonstrated both peripheral (inflammation, abnormal sympathetic ...) and central (neurological and cognitive) mechanisms.
Conclusion: A better knowledge of the physiopathology of complex pain syndrome type 1 is necessary in order to adapt efficient curative therapy or to a better prevention of this syndrome.

Keywords:

Pathophysiology; Complex regional pain syndrome; Treatment

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References

  1. Fontaine R, Teuwis S, Faymonville ME. Quoi de neuf dans le syndrome douloureux régional complexe (SDRC) encore appelé algoneurodystrophie? Douleur analg 2010; 23:42-50.
  2. Pélissier J, Viel E, Chauvineau V, Ricard C, Romain Met Hérisson C. Algodystrophie ou syndrome douloureux régional complexe de type I. EMC Kinésithérapie-Médecine physique-Réadaptation, 26-293-A-10, 2003.
  3. Janig W, Baron R. Complex regional pain syndrome is a disease of the central nervous system. Clin Auton Res 2002; 12:150-64.
  4. Pham T, Lafforgue P. Reflex sympathetic dystrophy syndrome and neuromediators. Joint Bone Spine 2003; 70:12-7.
  5. Huygen FJ, De Bruijn AG, De Bruin MT et al. Evidence for local inflammation in complex regional pain syndrome type 1. Mediators Inflamm 2002 ; 11:47-51.
  6. Birklein F. Complex regional pain syndrome. J Neurol 2005; 252:131-8.
  7. Birklein F, Schmelz M, Schifter S, Weber M. The important role of neuropeptides in complex regional pain syndrome. Neurology 2001; 57:2179-84.
  8. Weber M, Birklein F, Neundörfer B, Schmelz M. Facilitated neurogenic inflammation in complex regional pain syndrome. Pain 2001; 91:251-7.
  9. Bernateck M, Rolke R, Birklein F et al. Successful intravenous regional block with low-dose tumor necrosis factor-alpha antibody infliximab for treatment of complex regional pain syndrome 1. Anesth Analg 2007; 105:1148-51.
  10. Schwartzman RJ, Chevlen E, Bengtson K. Thalidomide has activity in treating complex regional pain syndrome. Arch Intern Med 2003; 163:1487-8.
  11. Blaes F, Schmitz K, Tschernatsch et al. Autoimmune etiology of complex regional pain syndrome (M. Sudeck). Neurology 2004 ; 63:1734-6.
  12. Goebel A, Vogel H, Caneris O et al. Immune response to campylobacter and serum antibodies in patients with complex regional pain syndrome. J Neuroimmunol 2005; 162:184-9.
  13. Gross O, Tschernatsch M, Braü ME et al. Increased seroprevalence of parvovirus B19 IgG in complex regional pain syndrome is not associated with antiendothelial autoimmunity. Eur J Pain 2007; 11:237-40.
  14. Christensen K, Jensen EM, Noer I. The reflex sympathetic dystrophy syndrome response to treatment with systemic corticosteroids. Acta Chir Scand 1982; 148:653-5.
  15. Goebel A, Stock M, Deacon R et al. Intravenous immunoglobulin response and evidence for pathogenic auto antibodies in a case of complex regional pain syndrome 1. Ann Neurol 2005; 57:463-4.
  16. Huygen FJ, Niehof S, Zijlstra FJ. Successful treatment of CRPS 1 with anti-TNF. J Pain Symptom Manag 2004; 27:101-3.
  17. Watkins LR, Maier SF. Immune regulation of central nervous functions: from sickness responses to pathological pain. J Intern Med 2005; 257:139-55.
  18. Coderre TJ, Xanthos DN, Francis L, Bennet GJ. Chronic postischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type 1 (CRPS-1; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain 2004; 112:94-105.
  19. Groeneweg JG, Huygen FJ, Heijmans-Antonissen C et al. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1. BMC Musculoskelet Disord 2006; 7:91.
  20. Eisenberg E, Shtahl S, Geller R et al. Serum and salivary oxidative analysis in complex regional pain syndrome. Pain 2008; 138:226-32.
  21. Perez RS, Zuurmond WW, Bezemer PD et al. The treatment of complex regional pain syndrome type 1 with free radical scavengers: a randomized controlled study. Pain 2003; 102:297- 307.
  22. Janig W, Baron R. Complex regional pain syndrome: mystery explained? The Lancet Neurology 2003; 2:687-97.
  23. Essaddam H. Nouvelle approche dans l'étude de l'appareil locomoteur et conséquences thérapeutiques. Tunis : CPU, 2007:323.