Kaposi’s disease: Epidemiological, clinical, anatomopathological and therapeutic features in 75 patients

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Published Mar 5, 2012
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Vol. 90 No. 2 (2012): Issue Feb 2012

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Inès Zaraa
Inès Zaraa
Imen Labbène
Nadia El Guellali
Nissaf Ben Alaya
Mourad Mokni
Amel Ben Osman

Abstract

Background: Kaposi’s sarcoma (KS) is a mutifocal angiogenic process characterized by cellular and vascular proliferation.
Aim: To identify the epidemio-clinical, histological and therapeutic features of KS.
Methods: Retrospective study of 75 cases of KS at the dermatology department of Rabta hospital in Tunis during a period of 25 years (1982-2007).
Results: Three epidemio-clinical forms of KS were observed in our study: the classic KS (70 cases), the AIDS-related KS (4 cases) and the iatrogenic KS (1 case). The mean age of our patients at diagnosis was 69.16 years with a sex ratio of 2.33. Elective site of cutaneous lesions in the classic KS was the limbs (87.1%). The cephalic part was concerned in 17.1% of cases. Mucosal involvement was found in 28.5% of patients. Extra dermatological localizations of KS were observed in 32.9%.
Conclusion: Our study identified some epidemio-clinical features of the classic KS especially the high frequency of mucosal and cephalic involvement as well as extra dermatological localizations. Thus further exploration is required even without alarm signs

Keywords:

Kaposi, AIDS, angiogenesis

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References

  1. Boué F, Lebbé C. Le sarcome de Kaposi. Bull Cancer 2003; 90: 393-8.
  2. Kaposi M. Idiopathic multiple pigmented sarcoma of the skin. Arch Dermatol Syphil 1872; 4: 265-73.
  3. Schulz TF, Sheldon J, Greensill J. Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8). Virus Res 2002; 82: 115-26.
  4. Ben Tekaya N, Zeglaoui F, Ben Abdallah T, et al. Maladie de Kaposi en Tunisia: revue de 91 cas. Tunis Med 2001; 79: 429-33.
  5. Brambilla L, Boneschi V, Taglioni M, Ferrucci S. Staging of classic Kaposi's sarcoma: a useful tool for therapeutic choices. Eur J Dermatol. 2003; 13: 83-6.
  6. Grayson W, Rantanowitz L. Histological variants of cutaneous Kaposi sarcoma. Diagn Pathol 2008; 3: 31.
  7. Idiopathic multiple pigmented sarcoma of the skin. Arch Dermatol Syphil 1872; 4: 265-73.
  8. Kourda M, Cheffai M. Les manifestations cutanéo-muqueuses de la maladie de Kaposi et du sarcome de Kaposi-SIDA. Maghreb Médical 1986; 146: 38-43.
  9. Ben Romdhane K, Sahnoun F, Kamoun MR, Ben Ayed M. Le sarcome de Kaposi en Tunisie: particularités anatomo-cliniques. A propos de 45 cas. Population et santé du Magreb 1989; 31: 1-3.
  10. Mseddi M, Marrekchi S, Abdelmaksoud W, et al. Profil épidémioclinique des cancers cutanés au sud Tunisien. Tunis Med 2007; 85: 505-8.
  11. Laor Y, Schwartz RA. Epidemiologic aspects of American Kaposi's sarcoma. J Surg Oncol 1979; 12: 299-303.
  12. Iscovich J, Boffetta P, Franceschi S, Azizi E, Sarid R. Classic Kaposi sarcoma: epidemiology and risk factors. Cancer 2000; 88: 500-17.
  13. Morand JJ, Lightburn E, Simon F, Patte JH. Actualités de la maladie de Kaposi. Med Trop 2007; 67: 123-30.
  14. Schwartz RA. Kaposi's sarcoma: advances and perspectives. J Am Acad Dermatol 1996; 34:804-14.
  15. Hengge UR, Ruzicka T, Tyring SK, et al. Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy. Lancet Infect Dis 2002; 2: 281-92
  16. Schwartz RA, Micali G, Nasca MR, Scuderi L. Kaposi sarcoma: A continuing conundrum. J Am Acad Dermatol 2008, 59: 179-206.
  17. Lebbé C, Kérob D. Maladie de Kaposi. Encycl Med Chir, Dermatologie 98-655-A-10, 2003, 11p.
  18. Maria S, Aversa L, Cattelan AM, et al. Treatments of AIDS - related Kaposi's sarcoma. Crit Rev Oncol Hematol 2005; 53: 253-65.
  19. Tazio Vanni, Eduardo Sprinz, Marcelo Warlet Machado, Rodrigo de C. Santana, Benedito Antonio L. Fonseca, Gilberto Schwartsmann. Systemic treatment of AIDS-related Kaposi sarcoma: Current status and perspectives. Cancer Treat Rev 2006; 32: 445-55.