Trastuzumab (herceptine) in medical therapy in breast cancer

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Published Jan 25, 2012
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Vol. 90 No. 1 (2012): Issue Jan 2012

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Lamia Bayoudh
Mehdi Afrit
Olfa Daldoul
M Zarrad
Hamouda Boussen

Abstract

Background: Trastuzumab is humanized monoclonal antibody targeting her 2 neu receptor, overexpressed in 20% of breast cancers and part of the complex of Epidermal Growth Factor Receptor.
Aim: To review new advances in the knowledge of the practical use of "trastuzumab (Herceptin ®)" in breast cancer.
Methods: Review of literature using medical data bases (Medline, Science direct) with the following key words: breast cancer, targeted therapy, HER2 neu, transtuzumab/herceptine
Résults : Trastuzumab represent an important advance in breast cancer treatment with an improvement of median survival in metastatic setting and overall and disease-free survival in adjuvant setting in association with chemotherapy. Herceptin remain well tolerated with a low and rare risk of cardiac failure.
Conclusion : Trastuzumab is a new therapeutic tool very intersting to ameliorate prognosis of reast cancer

Keywords:

Breast cancer; HER2neu; targeted therapy

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