Steatosis in chronic hepatitis C: Prevalence and predictive factors

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Published Dec 9, 2011
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Vol. 89 No. 11 (2011): Issue Nov 2011

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Asma Ouakaa-Kchaou
Service de Gastro-entérologie Hôpital H. Thameur Tunis
Dalila Gargouri
Service de Gastro-entérologie Hôpital H. Thameur Tunis
Asma Kochlef
Achraf Debbiche
Héla Elloumi
Mouna Ghouma
Afef Kilani
Malika Romani
Jamel Kharrat
Abdeljabbar Ghorbel

Abstract

Background: Patients with hepatitis C virus seem to often have hepatic steatosis.
Aim: To assess the prevalence and the predictive factors of steatosis during chronic hepatitis C.
Methods: We studied 50 HCV RNA positive subjects, who had liver biopsy performed. Steatosis was searched and patients were divided into to groups according to the presence or not of steatosis.
Results: On liver biopsy, 28 patients (56%) had steatosis. Multivariante analysis showed that steatosis was associated with age 58 years > 1,1 μmol/l, odds ratio 2 (95% CI 1.48 – 2.6; p= 0.02) and triglycerides level, odds ration 4,22 (95% CI 1.05 – 16.98; p = 0,03.
Conclusion: In this study, steatosis was significantly associated with metabolic factors.

Keywords:

Chronic hepatitis C; steatosis

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