Bellini renal cell carcinoma : Diagnosis and treatment. A report of 7 cases

##plugins.themes.academic_pro.article.sidebar##

Published Nov 1, 2011
Download
pdf
Vol. 89 No. 10 (2011): Issue Oct 2011

##plugins.themes.academic_pro.article.main##

Sataa Sallami
Monia Tanguour
Sami Ben Rhouma
Karim Cherif
Nidhameddine Kchir
Ali Horchani

Abstract

Background: The Bellini collecting duct carcinoma (CDC) is a very rare form of renal cell carcinoma (1%) associated with an extremely poor prognosis.
Aim: To study clinical and radiological characteristics of CDC.
Methods: From 1993 to 2002, 7 patients with CDC were treated at our institution. The diagnosis of CDC was made by a nephrectomy specimen in all cases. Demographic, clinical, pathological and survival data were gathered.
Results: They were five men and two women with an average age of 63 years. Lumbar pain and hematuria were the main symptoms. At presentation 2 T1N0M0, 1 T2N0M0, 1 T3N0M0, 1 T3N+M0 and 2 T4N+M+ tumors were seen. All patients underwent a radical nephrectomy. The two patients who had TNM stage I disease
survived without evidence of disease at 5 years and 11 years respectively. Patients with a T4N+M+ tumor experienced rapid progression and died respectively at 3 and 5 months after nephretomy. The 3 other patients with T3N+M0, T3N0M0 and T2N0M0 disease; respectively; progressed rapidly and were lost to follow-up after one year.
Conclusion: CDC is an aggressive variety of kidney neoplasm that is often associated with nodal and visceral metastases at presentation.It is associated with poor prognosis. For the majority of patients surgical treatment will not result in a cure. Early detection may be the best method for prolonging patient survival.

Keywords:

Renal cell carcinoma; Bellini collecting duct; metastasis; nephrectomy; poor prognosis

##plugins.themes.academic_pro.article.details##

References

  1. Chao D, Zisman A, Pantuck AJ, et al. Collecting duct renal cell carcinoma: clinical study of a rare tumor. J Urol. 2002; 167: 71-4.
  2. Rumpelt HJ, Störkel S, Moll R, Schärfe T, Thoenes W. Bellini duct carcinoma: further evidence for this rare variant of renal cell carcinoma. Histopathology. 1991; 18: 115-22.
  3. Carter MD, Tha S, McLoughlin MG, Owen DA. Collecting duct carcinoma of the kidney: a case report and review of the literature. J Urol. 1992; 147: 1096-8.
  4. Vigouroux V, Dugardin F, Bottet P, et al. Carcinome des tubes collecteurs de Bellini. A propos d'un cas. Prog Urol. 1998; 8: 249-53.
  5. Prati GF, Dean P, Firpo M, Moscatelli P, Saggin P, Muolo A. Bellini duct (collecting duct) carcinoma of the kidney. Int Urol Nephrol. 1998; 30: 677-80.
  6. Fleming S, Gibson AA. Proteinase inhibitors in the kidney and its tumours. Histopathology. 1986; 10: 1303-13.
  7. Méjean A, Rouprêt M, Larousserie F, Hopirtean V, Thiounn N, Dufour B. Is there a place for radical nephrectomy in the presence of metastatic collecting duct (Bellini) carcinoma? J Urol. 2003; 169: 1287-90.
  8. Peyromaure M, Thiounn N, Scotté F, Vieillefond A, Debré B, Oudard S. Collecting duct carcinoma of the kidney: a clinicopathological study of 9 cases. J Urol. 2003; 170: 1138-40.
  9. Dimopoulos MA, Logothetis CJ, Markowitz A, Sella A, Amato R, Ro J. Collecting duct carcinoma of the kidney. Br J Urol. 1993; 71: 388-91.
  10. Kennedy SM, Merino MJ, Linehan WM, Roberts JR, Robertson CN, Neumann RD. Collecting duct carcinoma of the kidney. Hum Pathol. 1990; 21: 449-56.
  11. Fondimare A, Bertrand G, Lagadec D. Carcinome des tubes collecteurs rénaux. Arch Anat Cytol Pathol. 1992; 40: 281-3.
  12. Miyamoto H, Kuwamitsu O, Moriyama M, et al. Bellini duct carcinoma of the kidney. Urol Int. 1992; 48: 460-2.
  13. Davis CJ Jr, Mostofi FK, Sesterhenn IA. Renal medullary carcinoma. The seventh sickle cell nephropathy. Am J Surg Pathol. 1995; 19: 1-11.
  14. Rousseau T, Lesourd A, Meria P, et al. Le carcinome des tubes de Bellini. Prog Urol. 1995; 5: 402-5.
  15. Fukuya T, Honda H, Goto K, et al. Computed tomographic findings of Bellini duct carcinoma of the kidney. J Comput Assist Tomogr. 1996; 20: 399-403.
  16. Schoenberg M, Cairns P, Brooks JD, et al. Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. Genes Chromosomes Cancer. 1995; 12: 76- 80.
  17. Füzesi L, Cober M, Mittermayer C. Collecting duct carcinoma: cytogenetic characterization. Histopathology. 1992; 21: 155-60.
  18. Störkel S, Van den Berg E. Morphological classification of renal cancer. World J Urol. 1995; 13: 153-8.
  19. Srigley JR, Eble JN. Collecting duct carcinoma of kidney. Semin Diagn Pathol. 1998; 15: 54-67.
  20. Yasunaga Y, Nishimura K, Takatera H, Fujioka H, Tsujimoto M. Bellini duct carcinoma treated with partial nephrectomy: a case report. Hinyokika Kiyo. 1994; 40: 1103-7.
  21. Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003; 27: 612-24.
  22. Roupret M, Peyromaure M, Hupertan V, et al. Carcinome à cellules rénales de Bellini : diagnostic et traitement. Prog Urol. 2004; 14: 564-7.