N-acetylcysteine in septic shock

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Published Oct 27, 2011
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Vol. 89 No. 10 (2011): Issue Oct 2011

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Omar Ellouze
Nabil Frikha
Service d'Anesthésie-Réanimation à CHU Mongi Slim - La Marsa - Tunisie
Sonia Ouerghi
Taher Mestiri
Mohamed Salah Ben Ammar
Service d'Anesthésie-Réanimation à CHU Mongi Slim - La Marsa - Tunisie

Abstract

Aim: To focus on the various studies evaluating the effects of Nacetylcysteine in septic shock
Methods: Main citationsRaws obtained from the medical database Medline using the keywords: N-acetylcysteine; septic shock, free radicals.
Results: Septic shock remains the leading cause of mortality in intensive care units. The progressive knowledge of the pathophysiology of septic shock, underline the production of free radicals and their cellular and microcirculatory effects. The Nacetylcysteine used mainly in paracetamol poisoning, has properties to control free radicals. The explosion of free radicals in septic shock has led to multiple studies assessing the role of N-acetylcysteine as an anti radical, and for its anti inflammatory action.
Conclusion: NAC seems to play an important role in septic shock to control free radicals and the inflammatory response. But these results remain contradictory. Some larger and more standardized studies should allow to evaluate the actual effects of NAC in septic shock.

Keywords:

N-acetylcysteine - septic shock - free radicals - ischaemia reperfusion injury

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