Clinicopathologic characteristics of low grade primary gastric non- Hodgkin's lymphomas: Experience from a single center

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Published Sep 14, 2011
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Vol. 89 No. 9 (2011): Issue Sep 2011

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Asma Ouakaa-Kchaou
Service de Gastro-entérologie Hôpital H. Thameur Tunis
Dalenda Gargouri
Asma Kochlef
H Elloumi
H Bouzid
A . kilani
M Romani
J Kharrat
Abdeljabbar Ghorbel

Abstract

Aim: To report the clinicopathological data and the treatment outcomes in patients with primary gastric low grade non-Hodgkin's lymphoma.
Methods: We carried out a retrospective analysis of 16 consecutive patients (median age 46 and range 28-75 years) who presented to our department with histopathological diagnosis of primary gastric low grade non-Hodgkin's lymphoma. We analyzed clinical manifestations, endoscopic features, pathological features,Helicobacter pylori infection and treatment.
Results: Common symptoms included abdominal pain (87.5%),vomiting (62.5%), and gastrointestinal bleeding (25%). Endoscopic appearances were mainly ulcers and ulcerations (93.75%).Endoscopic biopsy confirmation rate reached 87.5% when biopsies were repeated. Helicobacter pylori detection rate was 75%. A total of
9 patients received surgeries. Three patients had chemotherapy and 8 patients had Helicobacter pylori eradication therapy. The range of follow-up was 2-74 months with a median of 27 months. A complete remission was obtained in 12 cases, whereas 1 patient died and 3 were lost of view.
Conclusion: Eradication therapy may be offered as an initial treatment option in patients with low-grade gastric lymphoma.

Keywords:

Low grade primary gastric lymphoma; Epidemiology; Treatment

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