Intradiverticular tumors of the bladder: Diagnostic and therapeutic problems About 32 cases

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Sataa Sallami
Sami Ben Rhouma
Ghassen Hafsia
Yassine Nouira
Ali Horchani

Abstract

Background: The transitional cell carcinoma within the bladder diverticular is a rare and poorly known entity.
Aim: To evaluate diagnostic and therapeutic approaches of transitional cell carcinoma within the bladder diverticular.
Methods: Thirty men and two women (median: 70 years; 44- 83 years) were included. The main reason for consultation was hematuria. The intra-diverticular tumor was suspected by radiological assessment in 9 patients only. All these patients underwent an endoscopic resection of the tumor.
Results: The histological study concluded to a pta stage in 16 patients, pt1 stage in 8 patients and invasive tumors in 8 patients. A complementary endovesical BCG-therapy was performed in patients with superficial tumors and a radical cystectomy in patients with invasive tumors. With an average follow-up of 27 months, seven recurrences were found in the group of superficial tumors, including 3 cases of progression to invasive stage.
Conclusion: Bladder intra-diverticular tumors are rare and more common in elderly. In a bladder diverticulum, there are superficial tumors (pta, pt1) which are the most frequent and invasive tumors. Radical cystectomy is the gold standard for invasive tumors.Endoscopic resection combined with endo-vesical immunotherapy
should be reserved for superficial tumors.

Keywords:

Transitionnel cell carcinoma; bladder neoplasms; diverticulum; Bladder diverticulum

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References

  1. Fekak H, Rabu R, Joual A, et al. Les tumeurs de vessie intradiverticulaires. À propos de trois. Ann Urol (Paris). 2002;36:53-7.
  2. Zerbib M, Bouchot O. Tumeurs urothéliales intra-diverticulaires de vessie. Prog Urol. 2002; 12: 1109-11.
  3. Haecker A, Riedasch G, Langbein S, Alken P, Michel MS. Diverticular carcinoma of the urinary bladder: diagnosis and treatment problems. A case report. Med Princ Pract. 2005; 14: 121-4.
  4. Rozet F, Pfister C, Planet M, Sibert L, Grise P. Tumeur de vessie intra-diverticulaire: A propos de 5 cas. Prog Urol. 1997;21:225-8.
  5. Faysal MH, Freiha FS. Primary neoplasm in vesical diverticula. A report of 12 cases. Br J Urol. 1981; 53:141-3.
  6. Garzotto MG, Tewati AA, Wajsman Z. Multimodal therapy for neoplasms arising from a vesical diverticulum. J Surg Oncol. 1996; 62: 46-8.
  7. Melekos MD, Asbach HW, Barbalias GA. Vesical diverticula. Etiology, diagnosis, tumorgenesis and treatment: analysis of 74 cases. Urology. 1987; 30: 453-7.
  8. Das S, Amar AD. Vesical diverticulum associated with bladder carcinoma: therapeutic implications. J Urol. 1986; 136: 1013-4.
  9. Chopin D, Vordos D, Gattegno B. Etiologies des tumeurs superficielles de la vessie. Prog Urol. 2001; 11: 927-52.
  10. Redman JF, McGinnis TB, Bissada NK. Management of neoplasms in vesical diverticula. Urology. 1976; 7: 492-4.
  11. Dondalski M, White EM, Ghahremani GG, Patel SK. Carcinoma arising in urinary bladder diverticula: imaging findings in six patients. Am J Roentgenol. 1993; 161:817-20.
  12. Montague DK, Boltuch RL. Primary neoplasms in vesical diverticula: report of 10 cases. J Urol. 1976; 116: 41-2.
  13. Baniel J, Vishna T. Primary transitional cell carcinoma in vesical diverticula. Urology. 1997; 50: 697-9.
  14. Durfee SM, Schwartz LH, Panicek DM, Russo P. MR imaging of carcinoma within urinary bladder diverticulum. Clin Imaging. 1997; 21: 290-2.
  15. Micie S, Ilic V. Incidence of neoplasm in vesical diverticula. J Urol. 1983; 129: 734-5.
  16. Golijanin D, Yossepowitch O, Beck SD, Sogani P, Dalbagni G. Carcinoma in a bladder diverticulum: presentation and treatment outcome. J Urol. 2003; 170: 1761-4.